Gastric cancer (GC) is the second leading cause of cancer mortality and remains the fourth common cancer worldwide. The effective and feasible methods for predicting the possible outcomes for GC patients are still lacking. While genetic profiling might be suitable in some way, the application of gene expression signatures has been show to be a robust tool. Here, by performing a comprehensive search in PubMed, we provided an up-to-date summary of 39 prognostic gene signatures for GC patients, and described the processing procedure of the selection, calculation and construction of gene signature. We also reviewed current web tools including PROGgene and SurvExpress that can be used to analyze the prognostic value of multiple genes for GC. This review will aid in comprehensive understanding of the current prognostic gene signatures to accurately predict the outcome of GC patients, and may guide the future clinical management when the reliability of these signatures is validated in clinics.

中文翻译：

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胃癌患者预后基因特征的系统评价

胃癌 (GC) 是癌症死亡的第二大原因，并且仍然是全球第四大常见癌症。仍然缺乏有效和可行的方法来预测 GC 患者的可能结果。虽然基因分析在某些方面可能是合适的，但基因表达特征的应用已被证明是一种强大的工具。在这里，通过在 PubMed 中进行全面搜索，我们提供了 39 个 GC 患者预后基因签名的最新摘要，并描述了基因签名的选择、计算和构建的处理过程。我们还回顾了当前的网络工具，包括 PROGgene 和 SurvExpress，可用于分析多个基因对 GC 的预后价值。