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Midazolam Alters Acid-Base Status Less than Azaperone during the Capture and Transport of Southern White Rhinoceroses (Ceratotherium simum simum).
Animals ( IF 3 ) Pub Date : 2020-07-31 , DOI: 10.3390/ani10081323
Friederike Pohlin 1, 2, 3 , Peter Buss 2, 4 , Emma H Hooijberg 2, 5 , Leith C R Meyer 2, 3
Affiliation  

Acidemia represents a major life-threatening factor during rhinoceros capture. The acid-base status during rhinoceros transport is unknown. The purpose of this study was to describe changes in acid-base status during rhinoceros capture and transport and compare these changes between rhinoceroses sedated with azaperone or midazolam. Twenty-three wild white rhinoceros bulls were road-transported 280 km for reasons unrelated to this study. Rhinoceroses were captured with etorphine-azaperone (Group A) or etorphine-midazolam (Group M). During transport, azaperone (Group A) or midazolam (Group M) was re-administered every 2 h and venous blood collected. Changes in blood pH and associated variables were compared over time and between groups using a general linear mixed model. Rhinoceroses of both groups experienced a respiratory and metabolic acidosis during capture (pH 7.109 ± 0.099 and 7.196 ± 0.111 for Group A and Group M, respectively) that was quickly compensated for by the start of transport (pH 7.441 ± 0.035 and 7.430 ± 0.057) and remained stable throughout the journey. Rhinoceroses from Group M showed a smaller decrease in pH and associated variables at capture than rhinoceroses from Group A (p = 0.012). The use of midazolam instead of azaperone could therefore improve the success of rhinoceros capture and thus, contribute to the outcome of important conservation translocations.

中文翻译:

在南部白犀牛的捕获和运输过程中,咪达唑仑对酸碱的影响小于氮杂哌酮。

血酸血症是犀牛捕获过程中的主要威胁生命的因素。犀牛运输过程中的酸碱状态未知。这项研究的目的是描述在犀牛捕获和运输过程中酸碱状态的变化,并比较用氮杂哌酮或咪达唑仑镇静的犀牛之间的这些变化。由于与本研究无关的原因,有23头野生白犀牛公牛经公路运输了280公里。犀牛糖被依托啡嗪-氮杂哌酮(A组)或依托啡啶-咪达唑仑(M组)捕获。在运输过程中,每2小时重新给予azaperone(A组)或Midazolam(M组),并收集静脉血。使用一般线性混合模型比较了随时间推移以及各组之间血液pH值和相关变量的变化。两组犀牛在捕获过程中均发生呼吸性和代谢性酸中毒(A组和M组的pH分别为7.109±0.099和7.196±0.111),并在运输开始时迅速得到补偿(pH 7.441±0.035和7.430±0.057)并在整个旅程中保持稳定。与A组的犀牛相比,M组的犀牛在捕获时的pH值和相关变量的降低较小。p = 0.012)。因此,使用咪达唑仑代替氮杂哌酮可以提高犀牛捕获的成功率,因此有助于重要的保护易位。
更新日期:2020-07-31
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