It has been shown recently by Porter & Looger that a significant number of proteins exist that can form more than one stable fold. This note examines the sequences of these fold‐switching proteins by (a) calculating their foldability scores recently introduced by the present author and (b) comparing the propensity of chameleon sequences in fold switchers and in non fold switchers. It has been found that the average foldability score of the fold switchers indicates weaker foldability. As for the propensity of chameleon sequences of length 5 to 7 it was found, somewhat surprisingly, that there is only a very small difference between the fold switchers and the non fold switchers. Furthermore, when looking at amino acid propensities, for several amino acids there was even an opposing trend in the deviation of their propensities from the overall amino acid propensities.

中文翻译：

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折叠转换蛋白序列的可折叠性和变色龙倾向。

Porter & Looger 最近表明，存在大量可以形成不止一个稳定折叠的蛋白质。本说明通过 (a) 计算本作者最近介绍的它们的可折叠性分数和 (b) 比较折叠转换蛋白和非折叠转换蛋白中变色龙序列的倾向来检查这些折叠转换蛋白的序列。已经发现折叠开关的平均可折叠性分数表明可折叠性较弱。至于长度为 5 到 7 的变色龙序列的倾向，有些令人惊讶的是，折叠切换器和非折叠切换器之间只有非常小的差异。此外，在观察氨基酸倾向时，