Leishmania donovani, the causative agent for visceral leishmaniasis (VL), modulates host monocytes/macrophages to ensure its survival. However, knowledge regarding the host‐parasite interactions underpinning the disease remains limited. As disease progression is associated with polarization of monocytes/macrophages towards M2, which is regulated by cytokines IL‐4/IL‐13 and IL‐10, this study evaluated the status of key IL‐4‐ and IL‐10 driven markers in experimental models of VL, as also evaluated their correlation, if any, with parasite load.

中文翻译：

---

IL-4和IL-10驱动的标志物在内脏利什曼病的实验模型中的地位。

内脏利什曼病（VL）的病原体Leishmania donovani可调节宿主单核细胞/巨噬细胞，以确保其存活。然而，关于宿主-寄生虫相互作用基础疾病的知识仍然有限。由于疾病进展与单核细胞/巨噬细胞向M2的极化有关，这受细胞因子IL-4 / IL-13和IL-10的调节，因此本研究评估了实验性IL-4和IL-10驱动的关键标志物的状态VL模型也评估了它们与寄生虫负载的相关性（如果有）。