FGF20‐FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti,Developmental Dynamics

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FGF20‐FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti
Developmental Dynamics ( IF 2.0 ) Pub Date : 2020-07-31 , DOI: 10.1002/dvdy.231
Yutao Su ₁ , Lu M Yang ₁ , David M Ornitz ₁

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Fibroblast Growth Factor 20 (FGF20)‐FGF receptor 1 (FGFR1) signaling is essential for cochlear hair cell (HC) and supporting cell (SC) differentiation. In other organ systems, FGFR1 signals through several intracellular pathways including MAPK (ERK), PI3K, phospholipase C ɣ (PLCɣ), and p38. Previous studies implicated MAPK and PI3K pathways in HC and SC development. We hypothesized that one or both would be important downstream mediators of FGF20‐FGFR1 signaling for HC differentiation.

中文翻译：

FGF20-FGFR1 通过 MAPK 和 PI3K 信号传导控制 Corti 器官中的感觉祖细胞分化

成纤维细胞生长因子 20 (FGF20)-FGF 受体 1 (FGFR1) 信号传导对于耳蜗毛细胞 (HC) 和支持细胞 (SC) 的分化至关重要。在其他器官系统中，FGFR1 通过多种细胞内途径发出信号，包括 MAPK (ERK)、PI3K、磷脂酶 Cɣ (PLCɣ) 和 p38。先前的研究表明 MAPK 和 PI3K 通路参与 HC 和 SC 的发育。我们假设其中一个或两个将是 HC 分化的 FGF20-FGFR1 信号传导的重要下游介质。

更新日期：2020-07-31

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