Activity-Directed Synthesis: A Flexible Approach for Lead Generation.,ChemMedChem

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Activity-Directed Synthesis: A Flexible Approach for Lead Generation.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-07-30 , DOI: 10.1002/cmdc.202000524
George Karageorgis ₁ , Samuel Liver _{1,

2} , Adam Nelson _{1,

2}

Affiliation

Activity‐directed synthesis (ADS) is a structure‐blind, functional‐driven molecular discovery approach. In this Concept, four case studies highlight the general applicability of ADS and showcase its flexibility to support different medicinal chemistry strategies. ADS deliberately harnesses reactions with multiple possible outcomes, and allows many chemotypes to be evaluated in parallel. Resources are focused on bioactive molecules, which emerge in tandem with associated synthetic routes. Some of the future challenges for ADS are highlighted, including the realisation of an autonomous molecular discovery platform. The prospects for ADS to become a mainstream lead generation approach are discussed.

中文翻译：

活动导向综合：一种灵活的潜在客户开发方法。

活性定向合成（ADS）是一种结构盲、功能驱动的分子发现方法。在此概念中，四个案例研究强调了 ADS 的普遍适用性，并展示了其支持不同药物化学策略的灵活性。 ADS 有意利用具有多种可能结果的反应，并允许并行评估许多化学型。资源集中在生物活性分子上，这些分子与相关的合成路线同时出现。强调了 ADS 未来面临的一些挑战，包括实现自主分子发现平台。讨论了 ADS 成为主流潜在客户开发方法的前景。

更新日期：2020-10-05

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