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Anillin: The First Proofreading-like Scaffold?
BioEssays ( IF 3.2 ) Pub Date : 2020-07-31 , DOI: 10.1002/bies.202000055 Richard G Morris 1 , Kabir B Husain 2 , Srikanth Budnar 3 , Alpha S Yap 3
BioEssays ( IF 3.2 ) Pub Date : 2020-07-31 , DOI: 10.1002/bies.202000055 Richard G Morris 1 , Kabir B Husain 2 , Srikanth Budnar 3 , Alpha S Yap 3
Affiliation
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Scaffolds are fundamental to many cellular signaling pathways. In this essay, a novel class of scaffolds are proposed, whose action bears striking resemblance to kinetic proofreading. Commonly, scaffold proteins are thought to work as tethers, bringing different components of a pathway together to improve the likelihood of their interaction. However, recent studies show that the cytoskeletal scaffold, anillin, supports contractile signaling by a novel, non‐tethering mechanism that controls the membrane dissociation kinetics of RhoA. More generally, such proof‐reading‐like scaffolds are distinguished from tethers by a rare type of cooperativity, manifest as a super‐linear relationship between scaffold concentration and signaling efficiency. The evidence for this hypothesis is reviewed, its conceptual ramifications are considered, and research questions for the future are discussed.
中文翻译：
Anillin：第一个类似校对的脚手架？
支架是许多细胞信号通路的基础。在这篇文章中，提出了一类新的支架，其作用与动态校对有着惊人的相似之处。通常，支架蛋白被认为可以作为系绳发挥作用，将通路的不同成分结合在一起，以提高它们相互作用的可能性。然而，最近的研究表明，细胞骨架支架阿尼林通过一种控制 RhoA 膜解离动力学的新型非束缚机制支持收缩信号传导。更一般地说，这种类似校对的支架与系绳的区别在于一种罕见的协同性，表现为支架浓度和信号效率之间的超线性关系。审查了该假设的证据，考虑了其概念上的影响，
更新日期：2020-09-24
中文翻译：
Anillin：第一个类似校对的脚手架？
支架是许多细胞信号通路的基础。在这篇文章中，提出了一类新的支架，其作用与动态校对有着惊人的相似之处。通常，支架蛋白被认为可以作为系绳发挥作用，将通路的不同成分结合在一起，以提高它们相互作用的可能性。然而，最近的研究表明，细胞骨架支架阿尼林通过一种控制 RhoA 膜解离动力学的新型非束缚机制支持收缩信号传导。更一般地说，这种类似校对的支架与系绳的区别在于一种罕见的协同性，表现为支架浓度和信号效率之间的超线性关系。审查了该假设的证据，考虑了其概念上的影响，
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