The environmental complexity in which living organisms found themselves throughout evolution, most likely resulted in various encounters that would continuously challenge the organisms' ability to survive. Coping with this stress can prove energetically demanding and might require the proper coupling between mechanisms aimed at sensing external stimuli and cellular strategies geared at producing energy. In this issue of BioEssays, Lovejoy and Hogg hypothesize that preservation of this bifaceted coupling can be detected by the maintenance and evolution of stress response mechanisms at the genomic, molecular and cellular levels. Through ancestry‐tracking, they identify a group of related G protein‐coupled receptor systems with intersecting stress‐modulating properties which might represent an essential part of a complex organism's coping mechanisms to stress, an attribute that they suspect may be affected in individuals suffering from mood disorders such as depression.

中文翻译：

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应激反应GPCR进化枝的祖先追踪：治疗抑郁症的概念路径。

生命有机体在整个进化过程中发现自己的环境复杂性，很可能导致各种相遇，不断挑战生物体的生存能力。应对这种压力可能会带来精力上的需求，并且可能需要在旨在感测外部刺激的机制与旨在产生能量的细胞策略之间进行适当的耦合。在本期BioEssays，Lovejoy和Hogg假设可以通过在基因组，分子和细胞水平上维持和进化应激反应机制来检测这种双向偶联的保存。通过祖先追踪，他们确定了一组相关的G蛋白偶联受体系统，这些系统具有相交的压力调节特性，这可能代表复杂生物应对压力的机制的重要组成部分，他们怀疑这一特性可能会受到患有以下疾病的个体的影响情绪低落，例如抑郁。