Four Aspects about Solid-State Nanopores for Protein Sensing: Fabrication, Sensitivity, Selectivity, and Durability.,Advanced Healthcare Materials

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Four Aspects about Solid-State Nanopores for Protein Sensing: Fabrication, Sensitivity, Selectivity, and Durability.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-07-30 , DOI: 10.1002/adhm.202000933
Rui Hu ₁ , Xin Tong ₁ , Qing Zhao _{1,

2,

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Affiliation

Solid‐state nanopores are a mimic of innate biological nanopores embedded on lipid membranes. They are fabricated on thin suspended layers of synthetic materials that provide superior thermal, mechanical, chemical stability, and geometry flexibility. As their counterpart biological nanopores reach the goal of DNA sequencing and become commercial, solid‐state nanopores thrive in aspects of protein sensing and have become an important research component for clinical diagnostic technologies. This review focuses on resistive pulse sensing modes, which are versatile for low‐cost, portable sensing devices and summarizes four main aspects toward commercially available resistive pulse‐based protein sensing techniques using solid‐state nanopores. In each aspect of fabrication, sensitivity, selectivity, and durability, brief fundamentals are introduced and the challenges and improvements are discussed. The rapid advance of a practical technique requires greater multidisciplinary cooperation. The review aims at clarifying existing obstacles in solid‐state nanopore based protein sensing, intriguing readers with existing solutions and finally encouraging multidisciplinary researchers to advance the development of this promising protein sensing methodology.

中文翻译：

固态纳米孔用于蛋白质传感的四个方面：制备，敏感性，选择性和耐久性。

固态纳米孔是脂质膜上嵌入的天然生物纳米孔的模拟物。它们在合成材料的薄悬浮层上制造，可提供出色的热，机械，化学稳定性和几何形状灵活性。随着其对应的生物纳米孔达到DNA测序的目标并成为商业化产品，固态纳米孔在蛋白质传感方面蓬勃发展，并已成为临床诊断技术的重要研究组成部分。这篇综述着重介绍了电阻式脉冲传感模式，该模式可用于低成本，便携式传感设备，并总结了使用固态纳米孔的商用电阻式基于脉冲的蛋白质传感技术的四个主要方面。在制造，灵敏度，选择性和耐用性的各个方面，简要介绍了基本原理，并讨论了挑战和改进。实用技术的飞速发展需要更多的跨学科合作。这篇综述旨在阐明基于固态纳米孔的蛋白质传感技术中存在的障碍，使读者对现有解决方案产生兴趣，并最终鼓励多学科研究人员推动这一有前途的蛋白质传感方法的发展。

更新日期：2020-09-10

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