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Potential of Graphene–Polymer Composites for Ligament and Tendon Repair: A Review
Advanced Engineering Materials ( IF 3.4 ) Pub Date : 2020-07-30 , DOI: 10.1002/adem.202000492 Tânia Peixoto 1, 2 , Maria Conceição Paiva 2 , António T. Marques 3 , Maria A. Lopes 1
Advanced Engineering Materials ( IF 3.4 ) Pub Date : 2020-07-30 , DOI: 10.1002/adem.202000492 Tânia Peixoto 1, 2 , Maria Conceição Paiva 2 , António T. Marques 3 , Maria A. Lopes 1
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Tendon/ligament injuries are debilitating conditions that affect the life quality of a great percentage of the adult population. Several challenges still have to be addressed regarding the repair of these tissues, as current treatments show limited success. The use of biocompatible and biodegradable polymeric scaffolds potentially helps accomplish a complete and long‐term functional repair but, unfortunately, these materials lack adequate mechanical properties to be used in such demanding applications. Graphene is a subject of interest for tissue‐repair applications due to its electrical conductivity and mechanical properties. If incorporated adequately, it may significantly improve the physical properties of the composite, even at small loadings. Furthermore, graphene presents a biocompatible surface that may enhance cell adhesion, proliferation and differentiation and demonstrates promising outcomes in several in vitro and in vivo biological applications. Therefore, herein, the potential of graphene materials for the reinforcement of biodegradable polymers of interest for tendon/ligament repair is explored. The effect of graphene on relevant features such as mechanical properties, biodegradability, and biocompatibility is revised, to understand the feasibility of these composites to fulfill the requirements associated with these tissues and conclude how their applicability is extended to this field.
中文翻译：
石墨烯-聚合物复合材料对韧带和腱修复的潜力：综述
肌腱/韧带损伤是令人衰弱的状况，会影响很大一部分成年人口的生活质量。关于这些组织的修复，由于目前的治疗方法显示出有限的成功，因此仍然必须解决几个挑战。使用生物相容性和可生物降解的聚合物支架可能有助于完成完整和长期的功能修复，但不幸的是，这些材料缺乏足够的机械性能，无法用于此类苛刻的应用中。石墨烯因其导电性和机械性能而成为组织修复应用的关注主题。如果充分掺入，即使在小负荷下，它也可以显着改善复合材料的物理性能。此外，石墨烯具有生物相容性表面，可增强细胞黏附力，增殖和分化，并在多种体外和体内生物学应用中显示出令人鼓舞的结果。因此，在本文中，探索了石墨烯材料用于增强感兴趣的可生物降解的聚合物以进行肌腱/韧带修复的潜力。修订了石墨烯对相关特征（如机械性能，生物降解性和生物相容性）的影响，以了解这些复合材料满足与这些组织相关的要求的可行性，并得出结论，将其适用性扩展到该领域。
更新日期：2020-07-30
中文翻译：
石墨烯-聚合物复合材料对韧带和腱修复的潜力：综述
肌腱/韧带损伤是令人衰弱的状况，会影响很大一部分成年人口的生活质量。关于这些组织的修复，由于目前的治疗方法显示出有限的成功，因此仍然必须解决几个挑战。使用生物相容性和可生物降解的聚合物支架可能有助于完成完整和长期的功能修复，但不幸的是，这些材料缺乏足够的机械性能，无法用于此类苛刻的应用中。石墨烯因其导电性和机械性能而成为组织修复应用的关注主题。如果充分掺入，即使在小负荷下，它也可以显着改善复合材料的物理性能。此外，石墨烯具有生物相容性表面，可增强细胞黏附力，增殖和分化，并在多种体外和体内生物学应用中显示出令人鼓舞的结果。因此，在本文中，探索了石墨烯材料用于增强感兴趣的可生物降解的聚合物以进行肌腱/韧带修复的潜力。修订了石墨烯对相关特征（如机械性能，生物降解性和生物相容性）的影响，以了解这些复合材料满足与这些组织相关的要求的可行性，并得出结论，将其适用性扩展到该领域。
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