Purpose

The study aimed to translate and validate the Arabic version of General Medication Adherence Scale (GMAS) in Saudi patients with chronic diseases.

Methods

A multi-center cross sectional study was conducted for a month in out-patient wards of hospitals in Khobar, Dammam, Makkah, and Madinah, Saudi Arabia. Patients were randomly selected from a registered patient pools at hospitals and the item-subject ratio was kept at 1:20. The tool was assessed for factorial, construct, convergent, known group and predictive validities as well as, reliability and internal consistency of scale were also evaluated. Sensitivity, specificity, and accuracy were also evaluated. Data were analyzed using SPSS v24 and MedCalc v19.2. The study was approved by concerned ethics committees (IRB-129-25/6/1439) and (IRB-2019-05-002).

Results

A total of 282 responses were received. The values for normed fit index (NFI), comparative fit index (CFI), Tucker Lewis index (TLI) and incremental fit index (IFI) were 0.960, 0.979, 0.954 and 0.980. All values were >0.95. The value for root mean square error of approximation (RMSEA) was 0.059, i.e., <0.06. Hence, factorial validity was established. The average factor loading of the scale was 0.725, i.e., >0.7, that established convergent validity. Known group validity was established by obtaining significant p-value <0.05, for the associations based on hypotheses. Cronbach’s α was 0.865, i.e., >0.7. Predictive validity was established by evaluating odds ratios (OR) of demographic factors with adherence score using logistic regression. Sensitivity was 78.16%, specificity was 76.85% and, accuracy of the tool was 77.66%, i.e., >70%.

Conclusion

The Arabic version of GMAS achieved all required statistical parameters and was validated in Saudi patients with chronic diseases.

中文翻译：

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沙特阿拉伯慢性病患者一般药物依从性量表 (GMAS) 阿拉伯语版本的翻译和验证。

 目的

该研究旨在翻译和验证沙特慢性病患者的阿拉伯语版一般药物依从量表（GMAS）。

 方法

在沙特阿拉伯胡拜尔、达曼、麦加和麦地那的医院门诊病房进行了为期一个月的多中心横断面研究。患者是从医院登记的患者库中随机选择的，项目与受试者的比例保持在1:20。该工具的因子、构造、收敛、已知组和预测有效性进行了评估，并且量表的可靠性和内部一致性也得到了评估。还评估了敏感性、特异性和准确性。使用 SPSS v24 和 MedCalc v19.2 分析数据。该研究得到了相关伦理委员会 (IRB-129-25/6/1439) 和 (IRB-2019-05-002) 的批准。

 结果

共收到 282 份回复。规范拟合指数（NFI）、比较拟合指数（CFI）、塔克刘易斯指数（TLI）和增量拟合指数（IFI）的值为0.960、0.979、0.954和0.980。所有值为 >0.95。近似均方根误差(RMSEA)的值为0.059，即<0.06。因此，因子效度成立。量表的平均因子负荷为0.725，即>0.7，建立了收敛效度。对于基于假设的关联，通过获得显着的 p 值 <0.05 来建立已知的组有效性。 Cronbach's α 为0.865，即>0.7。通过使用逻辑回归评估人口因素的比值比 (OR) 与依从性评分来建立预测有效性。该工具的敏感性为78.16%，特异性为76.85%，准确度为77.66%，即>70%。

 结论

阿拉伯语版本的 GMAS 达到了所有必需的统计参数，并在沙特慢性病患者中得到了验证。