Background

Testing the hypoxic ventilatory response (HVR) at low-altitude helps to detect those who do not hyperventilate appropriately in hypoxia but might not necessarily predict the HVR and the risk to develop acute mountain sickness (AMS) at high altitude. However, a low HVR seems to be particularly prevalent in individuals susceptible to high-altitude pulmonary edema (HAPE+). In this short communication, we assessed differences in physiological parameters in two comparable women before and 3 hours after exposure to 3,480 meters. One woman had a (clinically diagnosed) history of high-altitude pulmonary edema (HAPE+) while the other did well at previous exposures to high altitude (HAPE-).

Methods

Heart rate, blood pressure, ventilation, arterial blood gas variables, arterial haemoglobin saturation, haemoglobin concentration, arterial oxygen content and delta plasma volume were measured or calculated before and after arrival at high altitude.

Results

At high altitude, plasma volume decreased in the HAPE- woman which in turn increased haemoglobin concentration. Ventilation was elevated in the HAPE- but not in the HAPE + woman. Arterial oxygen content fell in the HAPE + while it was preserved in the HAPE- woman. This resulted from lower peripheral oxygen saturation (-35%), lower haemoglobin concentration (-12%) and lower arterial partial pressure of oxygen (-59%) in the HAPE+.

Conclusion

Considerable haemoglobin desaturation and lack of haemoconcentration were characteristics of the HAPE + woman when exposed to high altitude, while the higher arterial oxygen content in the HAPE- woman was related to both haemoconcentration and hyperventilation (and associated haemoglobin saturation).

中文翻译：

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一名 HAPE 阳性和一名 HAPE 阴性女性在访问 3480 米之前和期间的氧气可用性。

背景

在低海拔测试低氧通气反应 (HVR) 有助于发现那些在缺氧时没有适当过度换气的人，但不一定能预测 HVR 和在高海拔发生急性高山病 (AMS) 的风险。然而，低 HVR 似乎在易患高海拔肺水肿 (HAPE+) 的个体中尤为普遍。在这次简短的交流中，我们评估了两名可比女性在暴露于 3,480 米之前和之后 3 小时的生理参数差异。一名妇女有（临床诊断）高原肺水肿 (HAPE+) 病史，而另一名妇女在先前暴露于高原 (HAPE-) 时表现良好。

方法

在到达高海拔之前和之后测量或计算心率、血压、通气量、动脉血气变量、动脉血红蛋白饱和度、血红蛋白浓度、动脉氧含量和delta血浆体积。

结果

在高海拔地区，HAPE-女性的血浆容量减少，这反过来又增加了血红蛋白浓度。HAPE- 的通气量升高，但 HAPE + 女性的通气量未升高。HAPE + 组的动脉氧含量下降，而 HAPE- 组的动脉氧含量保持不变。这是由于 HAPE+ 中较低的外周血氧饱和度 (-35%)、较低的血红蛋白浓度 (-12%) 和较低的动脉氧分压 (-59%)。

结论

当暴露于高海拔地区时，HAPE + 女性的血红蛋白饱和度显着降低和血液浓缩不足是其特征，而 HAPE- 女性的动脉氧含量较高与血液浓缩和换气过度（以及相关的血红蛋白饱和度）有关。