Because of our classification system limitations for defining psychiatric disorders and understanding their physiopathology, a new research area based on dimensions has emerged. It consists of exploring domains derived from fundamental behavioral components linked to neurobiological systems. Emotional processing is among the most affected dimensions in bipolar disorders (BD), but is excluded from the definition criteria. The purpose of this review is to synthesize the emotional responses disruption during the different phases of BD, using intensity and valence as the two key characteristics of emotions. We integrate those emotional disruptions into an original, emotion-based model contrasting with the current diagnostic frame built on mood. Emotional processing is underpinned by cortico-limbic circuits involving the amygdala. Recent publications showed the crucial role of the amygdala in emotional processes triggered by stimuli of negative, but also positive valence. We show how these neuroscience data can provide physiological basis for emotional disturbances observed in BD. We conclude with translational perspectives to improve the current knowledge about neural substrates underlying altered emotional responses characterizing BD.

由于我们的分类系统在定义精神疾病和理解其生理病理方面存在局限性，因此出现了一个基于维度的新研究领域。它包括探索从与神经生物学系统相关的基本行为成分衍生的领域。情绪加工是双相情感障碍（BD）中受影响最大的维度之一，但未从定义标准中排除。这篇综述的目的是使用强度和化合价作为情感的两个关键特征，综合BD不同阶段的情感反应中断。我们将这些情绪干扰整合到原始的基于情绪的模型中，与目前基于情绪的诊断框架形成对比。涉及杏仁核的皮质-边缘回路支持了情感加工。最近的出版物表明杏仁核在由负价刺激和正价刺激引起的情绪过程中起着至关重要的作用。我们展示了这些神经科学数据如何为BD中观察到的情绪障碍提供生理基础。我们以翻译的观点来结束，以改善有关表征BD的情绪变化的神经基础的当前知识。