Plasmacytoid dendritic cells (pDCs) are an immune subset specialized in the production of Type I Interferons (IFNs). They are characterized by co-expression of myeloid and lymphoid markers. Their developmental origin has been studied since their discovery and the identification of a myeloid progenitor capable of generating all dendritic cell (DC) subsets, including pDCs, led to their classification within the myeloid compartment. However, recent findings challenge this hypothesis and provide evidence for a lymphoid origin for the majority of pDCs ⁴⁶⁻⁴⁸. In this review we discuss and present the original myeloid and the newer lymphoid developmental trajectories of pDCs.

浆细胞样树突状细胞（pDC）是专门生产I型干扰素（IFN）的免疫亚群。它们的特征是髓样和淋巴样标志物的共表达。自从它们的发现和能够产生所有树突状细胞（DC）子集（包括pDC）的髓样祖细胞的鉴定以来，已经对其发展起源进行了研究，从而导致了它们在髓样区室中的分类。然而，最近的发现挑战了这一假设，并为大多数pDC ^46-48的淋巴来源提供了证据。在这篇综述中，我们讨论并提出了pDC的原始髓样和较新的淋巴样发展轨迹。