OBJECTIVE To study compliance and effectiveness of the mHealth nutrition and lifestyle coaching program Smarter Pregnancy in couples undergoing in vitro fertilization (IVF) treatment with or without intracytoplasmic sperm injection (ICSI). DESIGN Multicenter, single-blinded, randomized controlled trial, conducted from July 2014 to March 2017. SETTING IVF clinics. PATIENT(S) A total of 626 women undergoing IVF treatment with or without ICSI and 222 male partners. INTERVENTIONS(S) Couples were randomly assigned to the light (control group) or regular (intervention group) Smarter Pregnancy program. Both groups filled out a baseline screening questionnaire on nutrition and lifestyle behaviors, and the intervention group received coaching tailored to inadequate behaviors during the 24-week period. MAIN OUTCOME MEASURE(S) Difference in improvement of a composite dietary and lifestyle risk score for the intake of vegetables, fruits, folic acid supplements, smoking, and alcohol use after 24 weeks of the program. RESULT(S) Compared with control subjects, women and men in the intervention group showed a significantly larger improvement of inadequate nutrition behaviors after 24 weeks of coaching. At the same time, the women also showed a significantly larger improvement of inadequate lifestyle behaviors. CONCLUSION(S) The mHealth coaching program Smarter Pregnancy is effective and improves the most important nutritional and lifestyle behaviors among couples undergoing IVF/ICSI treatment. International multicenter randomized trials are recommended to study the effect of using Smarter Pregnancy on pregnancy, live birth, and neonatal outcome. NETHERLANDS TRIAL REGISTER NUMBER NTR4150.

中文翻译：

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针对接受体外受精治疗的不育夫妇的第一个有效的 mHealth 营养和生活方式指导计划：单盲多中心随机对照试验

目的 研究 mHealth 营养和生活方式指导计划 Smarter Pregnancy 在接受体外受精 (IVF) 治疗的夫妇中的依从性和有效性，使用或不使用卵胞浆内单精子注射 (ICSI)。设计 多中心、单盲、随机对照试验，于 2014 年 7 月至 2017 年 3 月进行。设置试管婴儿诊所。患者 共有 626 名接受 IVF 治疗的女性，伴或不伴 ICSI，222 名男性伴侣。干预措施 夫妇被随机分配到轻度（对照组）或常规（干预组）智能怀孕计划。两组都填写了一份关于营养和生活方式行为的基线筛查问卷，干预组在 24 周期间接受了针对不当行为的指导。主要结果测量 项目 24 周后，针对蔬菜、水果、叶酸补充剂、吸烟和饮酒的综合饮食和生活方式风险评分改善的差异。结果（S） 与对照组相比，干预组的女性和男性在接受 24 周的指导后，营养不足行为的改善明显更大。同时，女性对不适当的生活方式行为也表现出明显更大的改善。结论 移动健康指导计划 Smarter Pregnancy 是有效的，并改善了接受 IVF/ICSI 治疗的夫妇中最重要的营养和生活方式行为。推荐国际多中心随机试验研究使用智慧妊娠对妊娠、活产和新生儿结局的影响。