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Effect of pretreatment oral contraceptives on fresh and cumulative live birth in vitro fertilization outcomes in ovulatory women
Fertility and Sterility ( IF 6.6 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.fertnstert.2020.05.021
Yao Lu 1 , Yuan Wang 1 , Ting Zhang 1 , Guiquan Wang 2 , Yaqiong He 1 , Steven R Lindheim 3 , Zhangsheng Yu 4 , Yun Sun 1
Affiliation  

OBJECTIVE To evaluate the impact of oral contraceptives (OC) on live birth rate (LBR) following a fresh embryo transfer and cumulative live birth rate (cLBR) in normal ovulatory women undergoing in vitro fertilization (IVF). DESIGN Retrospective cohort study. SETTING Reproductive center. PATIENTS A total of 3,110 normo-ovulatory women aged 20-40 years undergoing IVF either using or not using OC pretreatment in their first autologous cycle. INTERVENTION(S) Patients initiated gonadotropins for their IVF cycle either after a spontaneous menses or following OC pretreatment, which was at the discretion of the provider or according to patients preference. MAIN OUTCOME MEASURE(S) The primary outcomes were LBR after fresh transfer (fLBR) and cLBR. RESULTS fLBR was significantly lower in women using OC compared to those not (42.6% vs. 52.8%). Although LBR after frozen embryo transfer cycles were similar (42.7% vs. 41.1%), cLBR was significantly lower in women using OC (62.8% vs. 67.6%). Multivariate logistic and COX regression analysis adjusting for baseline characteristics demonstrated that IVF cycle synchronization with OC was significantly associated with a lower fLBR (adjusted odds ratio 0.73, 95% confidence interval 0.62-0.86) and cLBR (adjusted hazard ratio 0.89, 95% confidence interval 0.80-0.98). CONCLUSIONS Pretreatment OC use is associated with a reduction in fLBR and cLBR.

中文翻译:

预处理口服避孕药对排卵妇女新鲜和累积活产体外受精结果的影响

目的 评估口服避孕药 (OC) 对接受体外受精 (IVF) 的正常排卵妇女新鲜胚胎移植后活产率 (LBR) 和累积活产率 (cLBR) 的影响。设计 回顾性队列研究。设置生殖中心。患者 共有 3,110 名 20-40 岁的正常排卵女性在第一个自体周期中使用或不使用 OC 预处理进行试管婴儿。干预措施 患者在自发月经后或 OC 预治疗后开始为他们的 IVF 周期使用促性腺激素,这由提供者自行决定或根据患者偏好。主要结果测量 主要结果是新鲜转移后的 LBR (fLBR) 和 cLBR。结果 与不使用 OC 的女性相比,使用 OC 的女性的 fLBR 显着降低(42.6% 对 52.8%)。尽管冷冻胚胎移植周期后的 LBR 相似(42.7% 对 41.1%),但使用 OC 的女性的 cLBR 显着较低(62.8% 对 67.6%)。调整基线特征的多变量逻辑和 COX 回归分析表明,IVF 周期与 OC 同步与较低的 fLBR(调整后的优势比 0.73,95% 置信区间 0.62-0.86)和 cLBR(调整后的风险比 0.89,95% 置信区间)显着相关0.80-0.98)。结论 预处理 OC 的使用与 fLBR 和 cLBR 的减少有关。调整基线特征的多变量逻辑和 COX 回归分析表明,IVF 周期与 OC 同步与较低的 fLBR(调整后的优势比 0.73,95% 置信区间 0.62-0.86)和 cLBR(调整后的风险比 0.89,95% 置信区间)显着相关0.80-0.98)。结论 预处理 OC 的使用与 fLBR 和 cLBR 的减少有关。调整基线特征的多变量逻辑和 COX 回归分析表明,IVF 周期与 OC 同步与较低的 fLBR(调整后的优势比 0.73,95% 置信区间 0.62-0.86)和 cLBR(调整后的风险比 0.89,95% 置信区间)显着相关0.80-0.98)。结论 预处理 OC 的使用与 fLBR 和 cLBR 的减少有关。
更新日期:2020-10-01
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