Fucoidan, a type of sulfated polysaccharide known for its anticoagulant, anti-tumor and anti-inflammatory effects, has been reported to have strong affinity towards P-selectin. P-selectin, which plays an important role in metastasis by enhancing the adhesion of cancer cells to endothelium and activated platelets in distant organs, is overexpressed on many cancer types. This study demonstrates the synthesis of a fucoidan-based drug delivery system for minimizing the side effects of doxorubicin (Dox) with the help of active targeting toward P-selectin. Fucoidan-doxorubicin nanoparticles (FU-Dox NPs), developed by direct conjugation of Dox to the fucoidan backbone, showed a well-controlled size distribution and sustained release. The active targeting capability of FU-Dox NPs toward P-selectin resulted in enhanced cellular uptake and cytotoxicity against the MDA-MB-231 cell line with high P-selectin expression compared to the MDA-MB-468 cell line with low P-selectin expression.

Fucoidan是一种硫酸多糖，因其抗凝，抗肿瘤和抗炎作用而闻名，据报道对P-选择蛋白具有很强的亲和力。P-选择素通过增强癌细胞对远处器官的内皮细胞和活化血小板的粘附在转移中起重要作用，在许多癌症类型中均过表达。这项研究证明了基于岩藻依聚糖的药物递送系统的合成，该系统可通过主动靶向P-选择素来最小化阿霉素（Dox）的副作用。通过将Dox直接缀合至岩藻依聚糖主链而开发的岩藻依聚糖-阿霉素纳米颗粒（FU-Dox NPs）表现出可控的大小分布和持续释放。