Astrocyte elevated gene-1 (AEG-1) is an oncogene and a critical signaling molecule that has a wide variety of interactions with other oncogenes and tumor suppressor genes, leading to increasing malignant properties of malignant gliomas, such as invasion, angiogenesis, metastasis, and chemoresistance. Its overexpression is enhanced by many factors such as exposure of the cells to human immunodeficiency virus type 1 (HIV-1), HIV-1 envelop glycoprotein 120, hypoxia, or glucose deprivation. Thorough understanding of these interactions along with AEG-1 inducers and repressors is important in setting a successful treatment plan targeting this oncogene. Since its discovery in 2002, AEG-1 has made a significant impact in improving our understanding of mechanism of malignant tumors progression, such as breast carcinomas, melanoma, and malignant gliomas. Therefore, it has been a novel therapeutic target for the past two decades. Herein, we focus on the role of AEG-1 in malignant gliomas and its interaction with other signaling molecules.

星形胶质细胞升高基因-1 (AEG-1) 是一种癌基因和关键信号分子，与其他癌基因和抑癌基因有多种相互作用，导致恶性胶质瘤的恶性特性增加，如侵袭、血管生成、转移、和化学抗性。它的过度表达受到许多因素的增强，例如细胞暴露于 1 型人类免疫缺陷病毒 (HIV-1)、HIV-1 包膜糖蛋白 120、缺氧或葡萄糖缺乏。彻底了解这些相互作用以及 AEG-1 诱导剂和阻遏物对于制定针对该癌基因的成功治疗计划非常重要。自 2002 年发现以来，AEG-1 对提高我们对乳腺癌、黑色素瘤和恶性胶质瘤等恶性肿瘤进展机制的理解产生了重大影响。因此，在过去的二十年里，它一直是一个新的治疗靶点。在此，我们关注 AEG-1 在恶性胶质瘤中的作用及其与其他信号分子的相互作用。