Recent UNAIDS reports (December 2019) indicate that 37.9 million people have been affected by HIV infection around the globe in 2018, of which 1.7 million are cited as new infections. Human immunodeficiency virus-1 (HIV-1) requires both the CD4 receptor, as the primary receptor, and a chemokine co-receptor to gain entry into the cell. In addition to the WT allele for C–C motif chemokine receptor 5 (CCR5-wt), there is another allele with a 32 bp deletion in the protein coding region (CCR5-Δ32). Individuals who are homozygous for the mutant allele are resistant towards M-tropic HIV infections. In the current study, we aimed to determine the CCR5-Δ32 allele frequency in the Turkish Cypriot population with 326 subjects, 141 men (43.1%) and 185 (56.9%) women. The region of the CCR5 gene containing the Δ32 deletion was amplified using flanking primers. The CCR5 gene Δ32 allele frequency was calculated at 3% and only observed in heterozygous individuals. We hope that our current publication could be a point of dialog between the physicians, the government officials and the public set up a more modern and well-structured HIV screening program in an effort to control and hopefully eliminate HIV from the Turkish Cypriot population.

中文翻译：

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土族塞人人群中的 CCR5-Δ32 基因变异频率

联合国艾滋病规划署最近的报告（2019 年 12 月）表明，2018 年全球有 3790 万人受到艾滋病毒感染的影响，其中 170 万人被列为新感染。人类免疫缺陷病毒-1 (HIV-1) 需要 CD4 受体（作为主要受体）和趋化因子辅助受体才能进入细胞。除了 C-C 基序趋化因子受体 5 (CCR5-wt) 的 WT 等位基因外，还有另一个等位基因在蛋白质编码区 (CCR5-Δ32) 中有 32 bp 的缺失。突变等位基因纯合的个体对 M 嗜性 HIV 感染具有抗性。在目前的研究中，我们旨在确定土族塞人人群中的 CCR5-Δ32 等位基因频率，包括 326 名受试者，141 名男性（43.1%）和 185 名（56.9%）女性。使用侧翼引物扩增含有 Δ32 缺失的 CCR5 基因区域。CCR5 基因 Δ32 等位基因频率计算为 3%，仅在杂合个体中观察到。我们希望我们当前的出版物可以成为医生、政府官员和公众之间的对话点，建立一个更现代和结构合理的 HIV 筛查计划，以努力控制并希望从土族塞人人口中消除 HIV。