Allergic rhinitis (AR) is nasal inflammation caused by allergy and the prevalence of AR is rising globally. In this investigation, we used ovalbumin-provoked AR to examine the antiallergic, anti-inflammation activities of mangiferin. Mangiferin is a xanthone found in higher plants as well as mango and it has numerous health benefits including antitumor, antioxidant, antimutagenic, antidiabetic, antibacterial, and anti-inflammatory properties. Alternatively, the antiallergic action of mangiferin on AR has been not yet investigated. Mangiferin administration reduced the symptoms of nasal allergy such as sneezing as well as rubbing in AR. Besides, the generated MDA through allergen administration was considerably diminished as a result of mangiferin treatment. Additionally, mangiferin prevented the STAT3 as well as NF-κBp65 signaling pathway activation in the cytosol, which resulted in the anti-inflammatory cytokines being upregulated, whereas, the pro-inflammatory cytokines were downregulated. Moreover, mangiferin reduced signs of ciliary loss, vascular congestion in the lamina, goblet cell elevation, and eosinophil filtration in the AR model. Hence, our findings suggest that mangiferin is a promising approach for immunotherapy in AR disease.

中文翻译：

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芒果苷通过抑制NF-κB信号通路对变应性鼻炎实验模型的抗炎作用

过敏性鼻炎（AR）是由过敏引起的鼻部炎症，全球范围内AR的患病率正在上升。在这项调查中，我们使用卵清蛋白诱发的AR来检查芒果苷的抗过敏，抗炎活性。芒果苷是一种在高等植物和芒果中发现的an吨酮，具有许多健康益处，包括抗肿瘤，抗氧化剂，抗诱变，抗糖尿病，抗菌和抗炎特性。或者，尚未研究芒果苷对AR的抗过敏作用。芒果苷的施用减轻了鼻部过敏的症状，例如打喷嚏和AR擦。此外，由于芒果苷治疗，通过过敏原施用产生的MDA大大减少。另外，芒果苷阻止了细胞溶质中的STAT3以及NF-κBp65信号通路的激活，这导致抗炎细胞因子被上调，而促炎细胞因子被下调。而且，芒果苷减少了AR模型中的纤毛消失，层板中的血管充血，杯状细胞升高和嗜酸性粒细胞过滤的迹象。因此，我们的研究结果表明芒果苷是AR疾病免疫治疗的一种有前途的方法。