We present a case of the patient, who developed hypersensitivity reaction during the treatment of chronic lymphocytic leukemia. Bendamustine was suspected as a culprit agent. The patient as well as 3 controls underwent skin testing with the concentrations of the bendamustine described in earlier studies. We doubted the testing recommendations as all the controls developed serious local reactions. The clinical meaning of the positive skin test reaction in the patient remained unclear and questioned the safeness of recommended testing concentrations as in certain situations wrong diagnosis could be made or even harm could be done. Future investigations are needed when allergy to bendamustine is suspected.

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苯达莫司汀的皮肤测试：应使用什么浓度？

我们介绍了一例在慢性淋巴细胞性白血病治疗期间出现超敏反应的患者。苯达莫司汀被怀疑是罪魁祸首。使用早期研究中所述的苯达莫司汀浓度对患者以及3名对照进行皮肤测试。我们对测试建议表示怀疑，因为所有控件都出现了严重的局部反应。病人皮肤测试反应阳性的临床意义尚不清楚，并质疑推荐的测试浓度的安全性，因为在某些情况下可能做出错误的诊断甚至可能造成伤害。当怀疑对苯达莫司汀过敏时，需要进一步的研究。