Covance Drug Development produces more than 55 million test results via its central laboratory services, requiring the delivery of more than 10 million reports annually to investigators at 35,000 sites in 89 countries. Historically, most of these data were delivered via fax or electronic data transfers in delimited text or SAS transport file format. Here, we present a new web portal that allows secure online delivery of laboratory results, reports, manuals, and training materials, and enables collaboration with investigational sites through alerts, announcements, and communications. By leveraging a three-tier architecture composed of preexisting data warehouses augmented with an application-specific relational database to store configuration data and materialized views for performance optimizations, a RESTful web application programming interface (API), and a browser-based single-page application for user access, the system offers greatly improved capabilities and user experience without requiring any changes to the underlying acquisition systems and data stores. Following a 3-month controlled rollout with 6,500 users at early-adopter sites, the Xcellerate Investigator Portal was deployed to all 240,000 of Covance’s Central Laboratory Services’ existing users, gaining widespread acceptance and pointing to significant benefits in productivity, convenience, and user experience.

Covance Drug Development 通过其中心实验室服务产生超过 5500 万份测试结果，每年需要向 89 个国家/地区 35,000 个地点的研究人员提供超过 1000 万份报告。从历史上看，这些数据中的大部分是通过传真或电子数据传输以分隔文本或 SAS 传输文件格式传送的。在这里，我们提供了一个新的门户网站，允许安全地在线交付实验室结果、报告、手册和培训材料，并通过警报、公告和通信与研究站点进行协作。通过利用由预先存在的数据仓库组成的三层架构，并通过特定于应用程序的关系数据库来存储配置数据和用于性能优化的物化视图，RESTful Web 应用程序编程接口 (API) 和用于用户访问的基于浏览器的单页应用程序，该系统提供了极大改进的功能和用户体验，而无需对底层采集系统和数据存储进行任何更改。在早期采用站点的 6,500 名用户进行为期 3 个月的受控部署后，Xcellerate Investigator Portal 已部署到 Covance 中心实验室服务的所有 240,000 名现有用户，获得广泛认可并指出在生产力、便利性和用户体验方面的显着优势.