Cardiovascular diseases are the leading cause of mortality and morbidity worldwide. Histone deacetylases (HDACs) play an important role in the epigenetic regulation of genetic transcription in response to stress or pathological conditions. HDACs interact with a complex co-regulatory network of transcriptional regulators, deacetylate histones or non-histone proteins, and modulate gene expression in the heart. The selective HDAC inhibitors have been considered to be a critical target for the treatment of cardiac disease, especially for ameliorating cardiac dysfunction. In this review, we discuss our current knowledge of the cellular and molecular basis of HDACs in mediating cardiac development and hypertrophy and related pharmacologic interventions in heart disease.

Impact statement

Histone deacetylases (HDACs) have recently been recognized as one of the most important regulated mechanism(s) in mediating cardiovascular development, myocardial injury, and hypertrophy. This detailed review of the functional role(s) and molecular mechanism(s) of histone deacetylase will provide the current view by which HDACs induce different biological signaling in the regulation of cardiac physiology and disease. More importantly, HDACs could be targeted to develop a new therapeutic strategy in treating cardiovascular disorders. Further studies of the specific roles and targets of HDACs will extend our knowledge of the biological impact and clinical implications of HDACs.

中文翻译：

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组蛋白去乙酰化酶调节心脏病及其临床转化和治疗意义。

心血管疾病是全球死亡率和发病率的主要原因。组蛋白去乙酰化酶 (HDAC) 在响应压力或病理条件的遗传转录的表观遗传调控中发挥重要作用。HDAC 与转录调节因子的复杂共调节网络相互作用，使组蛋白或非组蛋白脱乙酰化，并调节心脏中的基因表达。选择性 HDAC 抑制剂已被认为是治疗心脏病，尤其是改善心脏功能障碍的关键靶点。在这篇综述中，我们讨论了我们目前对 HDAC 介导心脏发育和肥大的细胞和分子基础的了解，以及心脏病的相关药物干预。

影响陈述

组蛋白去乙酰化酶 (HDAC) 最近被认为是介导心血管发育、心肌损伤和肥大的最重要的调节机制之一。对组蛋白去乙酰化酶的功能作用和分子机制的详细审查将提供当前的观点，即 HDAC 在心脏生理和疾病的调节中诱导不同的生物信号传导。更重要的是，可以针对 HDAC 开发一种新的治疗心血管疾病的治疗策略。对 HDAC 的具体作用和目标的进一步研究将扩展我们对 HDAC 的生物学影响和临床意义的认识。