Proximity-induced Pattern Operations in Reconfigurable DNA Origami Domino Array,Journal of the American Chemical Society

当前位置： X-MOL 学术 › J. Am. Chem. Soc. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Proximity-induced Pattern Operations in Reconfigurable DNA Origami Domino Array
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-07-29 , DOI: 10.1021/jacs.0c06061
Sisi Fan ₁ , Jin Cheng ₁ , Yan Liu ₁ , Dongfang Wang ₁ , Tao Luo ₁ , Bin Dai ₁ , Chuan Zhang ₂ , Daxiang Cui ₁ , Yonggang Ke ₃ , Jie Song _{1,

4}

Affiliation

Molecular patterns with nanoscale precision have been used to mimic complex molecular networks. One key challenge in molecular patterns is to perform active pattern operations in controllable systems to fully imitate their complex dynamic behaviors. Here, we present a reconfigurable DNA origami domino array-based dynamic pattern operation (DODA DPO) system to perform proximity-induced molecular control for complex pattern operations. The activatable platform of reconfigurable DODA endows a spontaneous cascade of stacking conformational transformation from the "before" to the "after" conformation by a set of "trigger" DNA strands. The conformational transformation further brings the operational pattern units into close proximity to undergo DNA strand displacement cascades to accomplish three different pattern operations of "writing", "erasing", and "shifting". Our results also demonstrate the reconfigurable DODA DPO system provides a useful basis to study various molecular control analysis in a fully programmable and controllable fashion.

中文翻译：

可重构 DNA 折纸多米诺阵列中的邻近诱导模式操作

具有纳米级精度的分子模式已被用于模拟复杂的分子网络。分子模式的一个关键挑战是在可控系统中执行主动模式操作，以完全模仿其复杂的动态行为。在这里，我们提出了一种可重构的基于 DNA 折纸多米诺阵列的动态模式操作 (DODA DPO) 系统，以执行复杂模式操作的接近诱导分子控制。可重构 DODA 的可激活平台通过一组“触发”DNA 链赋予从“之前”到“之后”构象的堆叠构象转换的自发级联。构象转换进一步使操作模式单元靠近进行DNA链置换级联，以完成“写入”、“擦除”和“移位”三种不同的模式操作。我们的结果还表明，可重构 DODA DPO 系统为以完全可编程和可控的方式研究各种分子控制分析提供了有用的基础。

更新日期：2020-07-29

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11