Heimiomycins A-C and Calamenens from the African Basidiomycete Heimiomyces sp.,Journal of Natural Products

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Heimiomycins A-C and Calamenens from the African Basidiomycete Heimiomyces sp.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-07-29 , DOI: 10.1021/acs.jnatprod.0c00486
Tian Cheng _{1,

2} , Clara Chepkirui _{1,

2} , Cony Decock ₃ , Josphat C Matasyoh ₄ , Marc Stadler _{1,

2}

Affiliation

Three previously undescribed compounds named heimiomycin A–C (1–3), featuring a unique scaffold with calamenene connected to a hydroxystyryl-pyranone moiety, along with the new calamenene derivatives 4 and 5 and phenanthridine derivative (6) were obtained from a culture of a Heimiomyces sp. This is the first report of the occurrence of calamenene-type terpenoids in fungi. Compound 3 exhibited antimicrobial activity against Gram-positive bacteria and Mucor hiemalis. Compounds 1 and 3 displayed moderate cytotoxicity against KB 3.1 and L929 cell lines, respectively.

中文翻译：

来自非洲担子菌 Heimiomyces sp. 的 Heimiomycins AC 和 Calamenens。

三种先前未描述的化合物，名为黑米霉素 A–C ( 1 – 3 )，具有独特的支架，其具有与羟基苯乙烯基 - 吡喃酮部分相连的葫芦烯，以及新的葫芦烯衍生物4和5以及菲啶衍生物 ( 6 ) 从培养物中获得a Heimiomyces sp. 这是首次报道真菌中存在calamenene型萜类化合物。化合物3表现出对革兰氏阳性菌和毛霉菌的抗菌活性。化合物1和3分别对 KB 3.1 和 L929 细胞系显示出中等的细胞毒性。

更新日期：2020-08-28

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