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Synthesis, Characterization, and Antibacterial Evaluation of Heteroleptic Oxytetracycline-Salicylaldehyde Complexes
Journal of Chemistry ( IF 2.8 ) Pub Date : 2020-07-30 , DOI: 10.1155/2020/7961345
Rohit Kumar Dev 1 , Parashuram Mishra 1 , Narendra Kumar Chaudhary 1, 2 , Ajaya Bhattarai 2
Affiliation  

A new series of mixed ligand complexes of Cd(II) and Mo(V) were successfully synthesized by refluxing the mixture solution of oxytetracycline hydrochloride (OTC.HCl) with an aqueous and alcoholic solution of metal (M = Cd(II) and Mo(V)) salts and an alcoholic solution of salicylaldehyde (Sal). The complexes were characterized by modern analytical and spectral methods such as elemental microanalysis, pH, conductivity, surface tension, viscosity, melting point, and spectral methods such as FT-IR, NMR, electronic absorption, SEM, and mass spectrometry. Conductivity measurements of the complexes revealed their electrolytic nature. The kinetic and thermal stabilities were investigated using thermogravimetric and differential thermal analysis techniques. Thermodynamic and kinetic parameters such as , , , and were calculated from TG curves using the Coats–Redfern method. Geometry optimization of the proposed structure of the complexes was achieved by running MM2 calculations in a Gaussian-supported CS ChemOffice 3D Pro.12.0 version software. The final optimized geometrical energies for respective Cd-OTC/Sal and Mo-OTC/Sal complexes were found to be 923.1740 and 899.3184 kcal/mol. The electronic absorption spectral study revealed a tetrahedral geometry for the Cd-OTC/Sal complex and octahedral geometry for the Mo-OTC/Sal complex. The antibacterial sensitivity of the complexes was evaluated against three bacterial pathogens such as S. aureus, E. coli, and P. mirabilis using the modified Kirby–Bauer paper disc diffusion method. The antibacterial study revealed significant growth inhibitory action of the complexes.

中文翻译:

杂配土霉素-水杨醛复合物的合成、表征和抗菌评价

将土霉素盐酸盐(OTC.HCl)与金属(M = Cd(II)和Mo)的水溶液和醇溶液回流,成功合成了一系列新的Cd(II)和Mo(V)混合配体配合物。 (V)) 盐和水杨醛 (Sal) 的醇溶液。通过现代分析和光谱方法(如元素微量分析、pH、电导率、表面张力、粘度、熔点)和光谱方法(如 FT-IR、NMR、电子吸收、SEM 和质谱)对配合物进行了表征。复合物的电导率测量揭示了它们的电解性质。使用热重分析和差热分析技术研究了动力学和热稳定性。热力学和动力学参数,例如 , , , 和使用 Coats-Redfern 方法从 TG 曲线计算。通过在支持高斯的 CS ChemOffice 3D Pro.12.0 版本软件中运行 MM2 计算,实现了复合物结构的几何优化。发现相应 Cd-OTC/Sal 和 Mo-OTC/Sal 复合物的最终优化几何能量为 923.1740 和 899.3184 kcal/mol。电子吸收光谱研究揭示了 Cd-OTC/Sal 配合物的四面体几何形状和 Mo-OTC/Sal 配合物的八面体几何形状。使用改良的柯比-鲍尔纸盘扩散法评估了复合物对三种细菌病原体的抗菌敏感性,如金黄色葡萄球菌、大肠杆菌和奇异假单胞菌。抗菌研究揭示了复合物的显着生长抑制作用。通过在支持高斯的 CS ChemOffice 3D Pro.12.0 版本软件中运行 MM2 计算,实现了复合物结构的几何优化。发现相应 Cd-OTC/Sal 和 Mo-OTC/Sal 复合物的最终优化几何能量为 923.1740 和 899.3184 kcal/mol。电子吸收光谱研究揭示了 Cd-OTC/Sal 配合物的四面体几何形状和 Mo-OTC/Sal 配合物的八面体几何形状。使用改良的柯比-鲍尔纸盘扩散法评估复合物对三种细菌病原体的抗菌敏感性,如金黄色葡萄球菌、大肠杆菌和奇异假单胞菌。抗菌研究揭示了复合物的显着生长抑制作用。通过在支持高斯的 CS ChemOffice 3D Pro.12.0 版本软件中运行 MM2 计算,实现了复合物结构的几何优化。发现相应 Cd-OTC/Sal 和 Mo-OTC/Sal 复合物的最终优化几何能量为 923.1740 和 899.3184 kcal/mol。电子吸收光谱研究揭示了 Cd-OTC/Sal 配合物的四面体几何形状和 Mo-OTC/Sal 配合物的八面体几何形状。使用改良的柯比-鲍尔纸盘扩散法评估复合物对三种细菌病原体的抗菌敏感性,如金黄色葡萄球菌、大肠杆菌和奇异假单胞菌。抗菌研究揭示了复合物的显着生长抑制作用。
更新日期:2020-07-30
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