Aging and longevity are complex processes controlled at different levels, including genetic level. We evaluated the association of seven drug and DNA-repair gene polymorphisms with longevity in an Italian cohort. A sample of 756 subjects aged 18-98 was genotyped for CYP1A1 exon 7 A>G, GSTT1 null, GSTM1 null, GSTP A>G, XRCC1 exon 6 C>T, XRCC1 exon 9 A> G and XPC exon 15 A>C gene polymorphisms. The association between the analyzed gene polymorphisms and longevity was evaluated by dividing the sample into three age groups: 10-50, 51-85, and 86-98. We observed a significant decrease in the frequency of the GSTT1 null, GSTP G and XPC C alleles in the oldest group with respect to the youngest one and with respect to 51-85 age group. We obtained the same results also subdividing the sample into 1-85 and 86-98 age groups. The general linear model analyses confirmed a significant decreasing trend of the above mentioned alleles with age. We hypothesized that these minor alleles, being important in the sensitivity against the development of different types of cancer, may reflect a reduced life-expectancy in carrier subjects and may explain their significantly lower frequency observed among subjects belonging to oldest age group.

中文翻译：

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代谢和DNA修复基因多态性与长寿的关联：GSTT1，GSTP和XPC基因的作用。

衰老和长寿是在不同水平（包括遗传水平）控制的复杂过程。我们在一个意大利队列中评估了7种药物和DNA修复基因多态性与长寿的相关性。对756名年龄在18-98岁的受试者的样本进行了CYP1A1外显子7 A> G，GSTT1无，GSTM1无，GSTP A> G，XRCC1外显子6 C> T，XRCC1外显子9 A> G和XPC外显子15 A> C的基因分型。基因多态性。通过将样本分为三个年龄段：10-50、51-85和86-98，评估了分析的基因多态性与寿命之间的关联。我们观察到年龄最大的一组和年龄最小的51-85岁年龄组中，GSTT1无，GSTP G和XPC C等位基因的频率显着降低。我们也获得了相同的结果，还将样本分为1-85岁和86-98岁年龄段。一般线性模型分析证实了上述等位基因随年龄的显着下降趋势。我们假设这些较小的等位基因对抵抗不同类型癌症的发展具有重要意义，可能反映出携带者的预期寿命缩短，并且可以解释在年龄最大的人群中观察到的频率显着降低。