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Cell-to-cell Mathematical Modeling of Arrhythmia Phenomena in the Heart
bioRxiv - Biophysics Pub Date : 2020-07-29 , DOI: 10.1101/2020.07.28.225755
Gabriel López Garza , A. Nicolás Mata , G. Román Alonso , J. F. Godínez Fernández , M. A. Castro García

With an aperiodic, self-similar distribution of two-dimensional arrangement of atrial cells, it is possible to simulate such phenomena as Fibrillation, Fluttering, and a sequence of Fibrillation-Fluttering. The topology of a network of cells may facilitate the initiation and development of arrhythmias such as Fluttering and Fibrillation. Using a GPU parallel architecture, two basic cell topologies were considered in this simulation, an aperiodic, fractal distribution of connections among 462 cells, and a chessboard-like geometry of 60x60 and 600x600 cells. With a complex set of initial conditions, it is possible to produce tissue behavior that may be identified with arrhythmias. Finally, we found several sets of initial conditions that show how a mesh of cells may exhibit Fibrillation that evolves into Fluttering.

中文翻译:

心脏心律不齐现象的细胞间数学建模

通过心房细胞二维排列的非周期性,自相似分布,可以模拟诸如颤动,颤动和颤动-颤动序列之类的现象。细胞网络的拓扑结构可以促进心律不齐的发生和发展,例如颤动和颤动。使用GPU并行体系结构,在此仿真中考虑了两种基本的单元拓扑,即462个单元之间连接的非周期性分形分布,以及60x60和600x600单元的棋盘状几何形状。在一组复杂的初始条件下,可能会产生心律失常所识别的组织行为。最后,我们发现了几组初始条件,这些初始条件显示了一个细胞网如何表现出颤动,并逐渐演变为颤动。
更新日期:2020-07-30
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