Infection with malarial parasites renders hosts more mosquito attractive than their uninfected, healthy, counterparts. One volatile organic compound, α-pinene, is associated with Plasmodium spp. infection in multiple studies and is a known mosquito attractant. However, how malarial infection results in elevated levels of host-associated α-pinene remains unclear. One study suggests that erythrocyte exposure to the malarial metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), results in increased levels of α-pinene. Here, we establish that endogenous levels of α-pinene are present in human erythrocytes, that these levels vary widely by erythrocyte donor, and that α-pinene levels are not altered by HMBPP treatment.

中文翻译：

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疟疾代谢物HMBPP不会触发红细胞萜烯的产生

与未感染，健康的对等体相比，感染了疟原虫的寄主使蚊子更具吸引力。一种挥发性有机化合物，α-pine烯，与疟原虫属。在多项研究中感染是已知的蚊子引诱剂。然而，还不清楚疟疾感染如何导致宿主相关的α-pine烯水平升高。一项研究表明，红血球暴露于疟疾代谢产物（E）-4-羟基-3-甲基-丁-2-烯基焦磷酸盐（HMBPP），会导致α-pine烯水平升高。在这里，我们确定人类红细胞中存在内源性α-pine烯水平，这些水平因红细胞供体而有很大差异，并且HMBPP处理不会改变α-pine烯水平。