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Antimalarial lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma sp.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2020-07-30 , DOI: 10.1038/s41429-020-0357-7
Masahiko Isaka 1 , Malipan Sappan 1 , Wilunda Choowong 1 , Thitiya Boonpratuang 2 , Rattaket Choeyklin 2 , Tao Feng 3 , Ji-Kai Liu 3
Affiliation  

Ten previously undescribed lanostane-type triterpenoids (110), together with 15 known lanostanes, were isolated from artificially cultivated fruiting bodies of the basidiomycete Ganoderma sp. BCC 21329. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data and by application of the modified Mosher’s method. Compounds 1, 3, 5, and 7 showed moderate antimalarial activity (IC50 3.8–7.6 μg ml−1).



中文翻译:

源自担子菌灵芝菌子实体的抗疟疾羊毛脂三萜类化合物。

十以前未描述羊毛甾烷型三萜类化合物(1 - 10),15个已知lanostanes一起,从的担子菌人工培育子实体灵芝属 BCC 21329.根据NMR光谱和质谱数据,并采用改进的Mosher方法对结构进行了阐明。化合物135,和7表现出中等抗疟疾活性(IC 50 3.8-7.6微克毫升-1)。

更新日期:2020-07-30
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