Abstract

Background

Although many theories have been established to explain the mechanism of aneurysm development following steno-occlusive or hypertensive disease, the effect of the geometrical shape of the inner elastic membrane on the maximum dilatation capacity of arteries has not been adequately investigated so far. This subject was investigated.

Methods

This study was conducted in 24 rabbits. The rabbits were divided into 3 groups: as the control, (n = 5), the SHAM (n = 5), and the study group (n = 14). In the study group, BCCAL was performed. After decapitation, the basilar artery vasodilatation index (VDI) and the actual length of the inner elastic membrane (IEM) were estimated. The relationship between the true length of IEM and VDI values was compared statistically using the Mann-Witney –U test.

Results

Mean blood pressures were 113 ± 7 mmHg in animals at the beginning of the experiment (n = 24), and 119 ± 9 mmHg in GII and 122 ± 11mmHg in GIII after BCCAL (n = 12). Before decapitation, the mean blood pressures were 115 ± 10 mmHg in GI, 116 ± 10 mmHg in GII, and 127 ± 11mmHg GIII. The DADA values of animals were 20 ± 4mm in GI; 28 ± 6mm in GII and 37 ± 9mm in GIII. The VDI value of BA was 1.390 ± 0.220 in GI; 1.013 ± 0.108 in GI; 0.019 ± 0.011in GII group.

Conclusion

An inverse relationship was discovered between the DADA/VDI values. BCCAL may lead to severe dangerous histopathological changes at the BA. Lower DADA or higher VDI values may lead to severe basilar enlargement, endothelial losing, inner elastic membrane rupture, and aneurysm formation after BCCAL.

中文翻译：

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双侧颈总动脉结扎后动脉危险报警直径（DADA）估计基底动脉破裂上限；一个新定理

摘要

背景

尽管已经建立了许多理论来解释狭窄闭塞或高血压疾病后动脉瘤发展的机制，但迄今为止尚未充分研究内弹性膜的几何形状对动脉最大扩张能力的影响。对此课题进行了调查。

方法

这项研究是在 24 只兔子中进行的。将兔子分为3组：对照组（n  = 5）、SHAM组（n  = 5）和研究组（n  = 14）。在研究组中，进行了BCCAL。断头后，估计基底动脉血管舒张指数（VDI）和内弹性膜的实际长度（IEM）。使用 Mann-Witney –U 检验统计比较 IEM 的真实长度和 VDI 值之间的关系。

结果

实验开始时动物的平均血压为 113 ± 7 mmHg（n  = 24），BCCAL 后 GII 为 119 ± 9 mmHg，GIII 为 122 ± 11 mmHg（n  = 12）。斩首前，GI 的平均血压为 115 ± 10 mmHg，GII 为 116 ± 10 mmHg，GIII 为 127 ± 11 mmHg。动物的 DADA 值在 GI 为 20 ± 4mm；GII 为 28 ± 6 毫米，GIII 为 37 ± 9 毫米。BA的VDI值GI为1.390±0.220；GI 1.013 ± 0.108；GII 组为 0.019 ± 0.011。

结论

发现 DADA/VDI 值之间存在反比关系。BCCAL 可能导致 BA 发生严重危险的组织病理学变化。较低的 DADA 或较高的 VDI 值可能导致 BCCAL 后严重的基底增大、内皮丢失、内弹性膜破裂和动脉瘤形成。