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Coronavirus disease - COVID-19: new perceptives towards epidemic to pandemic.
Journal of Drug Targeting ( IF 4.3 ) Pub Date : 2020-08-12 , DOI: 10.1080/1061186x.2020.1803885
S B Santhosh 1, 2 , A Mohamed Sheik Tharik 1, 2 , M Susitra Manjari 3 , R Balakrishnan 4 , N Muruganandam 5 , M J N Chandrasekar 1, 2
Affiliation  

The sudden outbreak and uncontrolled spread of the novel coronavirus disease 2019 (COVID-19) has shocked the world to a degree never seen before. Due to the wide spread transmission of the virus, the number of infected cases worldwide has surpassed 16,421,958 and global death toll has spiked up to 6,52,308 from December 2019 to 27 July 2020. The virus has been labelled as a pandemic by the WHO. Virologists have found that this virus outbreak is similar to past outbreaks of viruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome that caused severe respiratory syndrome and transmitted rapidly in humans. These single stranded RNA viruses come under the genera of β-coronaviruses which ultimately infect lungs and respiratory tract. Even though the origin, source and intermediate hosts of this virus is unknown, transmittance from human-to-human through various paths has been identified globally. As of today, there are no approved drugs and vaccines. Several clinical trials are being conducted today to evaluate vaccines against the virus. The aim of our present review is to furnish brief details about the statistics, diagnosis, epidemiology, pathogenesis, prevention and treatment of COVID-19 to assist researchers and the society at large to come to grip with the deadly disease.

  • Highlights
  • Cumbersome outbreak of the novel Coronavirus Disease 2019 (COVID-19) became a pandemic

  • At June 19, 2020, as per WHO report 8,618,787 infected cases and 457,275 dead were recorded globally

  • Major spread was found to be human to human transmissions

  • People with positive COVID-19 were infected with severe respiratory syndrome

  • More animal and clinical studies have to be done to overcome this pandemic



中文翻译:

冠状病毒疾病-COVID-19:对流行病到大流行病的新认识。

新的冠状病毒病2019(COVID-19)的突然爆发和无节制的传播震惊了世界,前所未有的程度。由于该病毒的广泛传播,从2019年12月至2020年7月27日,全球感染病例数已超过16,421,958,全球死亡人数飙升至6,52,308。该病毒被WHO标记为大流行病。病毒学家发现,这种病毒的爆发与过去引起严重呼吸综合症并在人类中迅速传播的严重急性呼吸综合症冠状病毒(SARS-CoV)和中东呼吸综合症等病毒相似。这些单链RNA病毒属于β冠状病毒,最终感染肺和呼吸道。即使出身 该病毒的来源和中间宿主尚不清楚,全球范围内已确定了人与人之间通过各种途径的传播。截至今天,尚无批准的药物和疫苗。今天正在进行多项临床试验,以评估针对该病毒的疫苗。我们本次审查的目的是提供有关COVID-19的统计,诊断,流行病学,发病机制,预防和治疗的简要信息,以帮助研究人员和整个社会应对这种致命疾病。

  • 强调
  • 新型冠状病毒病2019(COVID-19)的繁复爆发大流行

  • 截至2020年6月19日,根据世界卫生组织的报告,全球记录了8,618,787例感染病例和457,275例死亡

  • 发现主要传播是人与人之间的传播

  • COVID-19阳性的人感染了严重的呼吸综合征

  • 为了克服这种流行病,还需要进行更多的动物和临床研究

更新日期:2020-08-27
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