ABSTRACT

The current study was conducted to assess the prevalence and odds ratio (OR) of co-infection of Helicobacter pylori (H. pylori) and intestinal parasites (IPs). English databases were searched. A total of 18 studies including 14 studies with cross-sectional design (a total of 3739 participants) and 4 studies with case-control design (397 patients and 320 controls) met the eligibility criteria. The pooled prevalence of H. pylori, intestinal parasite infections (IPIs), and their co-infections in different populations were 48.3% (95% CI, 34.1–62.8%), 15.4% (95% CI, 10–22.8%), and 11% (95% CI, 6.7–17.6%), respectively. The co-infection of H. pylori and Giardia was 7.6% (95% CI, 4.9–11.7%). Although statistically not significant, the risk of co-infection of H. pylori and IPIs was higher in case group compared to control group (OR, 1.59; 95% CI, 0.77–3.25). The overlaps between H. pylori and IPIs in countries with lower human development index (HDI) and income levels were high.

摘要

本研究旨在评估幽门螺杆菌( H. pylori ) 和肠道寄生虫 (IPs) 共感染的患病率和优势比 (OR)。搜索了英文数据库。共有 18 项研究，包括 14 项横断面设计研究（共 3739 名受试者）和 4 项病例对照设计研究（397 名患者和 320 名对照）符合纳入标准。H. pylori、肠道寄生虫感染 (IPIs) 及其在不同人群中的合并感染率分别为 48.3% (95% CI, 34.1–62.8%)、15.4% (95% CI, 10–22.8%)、和 11% (95% CI, 6.7–17.6%)。幽门螺杆菌和贾第鞭毛虫的共同感染为 7.6%（95% CI，4.9–11.7%）。虽然在统计学上不显着，但与对照组相比，病例组幽门螺杆菌和 IPI的共同感染风险更高（OR，1.59；95% CI，0.77-3.25）。在人类发展指数 (HDI) 和收入水平较低的国家，幽门螺杆菌和 IPI之间的重叠很高。