A novel and efficient catalyst system was developed for homocoupling reactions of aryl halides. The catalyst system consists of Pd(OAc)2 and the peppery sensory component of tobacco leaves. This is the first time that a sensory component has been used in an organic reaction. Experiments using the catalyst system showed that the reactions proceeded smoothly under air in the absence of both an additional ligand and a reductant. Furthermore, the catalyst system can be applied to the coupling reactions of hetaryl iodides. Many functional groups (including a hydroxy group) are tolerated.

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钯/感觉组分催化芳基卤化物的均偶联反应

开发了一种用于芳基卤化物均偶联反应的新型高效催化剂体系。催化剂体系由 Pd(OAc)2 和烟叶的辛辣感官成分组成。这是第一次将感官成分用于有机反应。使用催化剂体系的实验表明，在没有额外配体和还原剂的情况下，反应在空气中顺利进行。此外，该催化剂体系可用于杂芳基碘的偶联反应。许多官能团（包括羟基）是可以容忍的。