Lycium barbarum berry (gouqi, Goji, goji berry, or wolfberry), a traditional medicine and functional food, has a wide range of biological effects, including immuno‐modulation, anti‐aging, antitumor, neuro‐protection, and hepato‐protection. However, thus far, little is known about the traditional effects of L. barbarum on strengthening muscles. Therefore, this study focused on the effects of an extract of L. barbarum on skeletal muscles. First, the extract of L. barbarum significantly increased the mass of the tibial anterior muscle and gastrocnemius muscle and improved the average running distance of mice. Then, in vivo and in vitro experiments showed that the extract enhanced muscle endurance by increasing the proportion of type IIa oxidative muscle fibers and aerobic respiration. In an in‐depth study of the molecular mechanism of these effects, we found that the extract upregulated the proportion of type IIa oxidative muscle fibers by activating ERRγ and that the PKA‐CREB signaling pathway was involved in its activation. This study is the first to show that L. barbarum extract modulates skeletal muscle remodeling and has mimetic effects on skeletal muscles in a manner similar to exercise. It provides a scientific explanation based on modern biological technologies and concepts for the traditional function of L. barbarum in improving muscle fitness. This study lays a theoretical foundation for the application of L. barbarum in skeletal muscles as an exercise mimetic.

中文翻译：

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枸杞提取物模拟运动，通过激活 ERRγ 增加 IIa 型氧化肌纤维来提高肌肉耐力

枸杞（枸杞、枸杞、枸杞或枸杞）是一种传统药物和功能性食品，具有广泛的生物学作用，包括免疫调节、抗衰老、抗肿瘤、神经保护和保肝。然而，到目前为止，人们对枸杞在增强肌肉方面的传统作用知之甚少。因此，本研究侧重于枸杞提取物对骨骼肌的影响。首先，枸杞提取物显着增加了胫前肌和腓肠肌的质量，提高了小鼠的平均跑步距离。然后，体内和体外实验表明，提取物通过增加 IIa 型氧化肌纤维和有氧呼吸的比例来增强肌肉耐力。在深入研究这些效应的分子机制中，我们发现提取物通过激活 ERRγ 上调了 IIa 型氧化肌纤维的比例，并且 PKA-CREB ​​信号通路参与了它的激活。这项研究首次表明，枸杞提取物可调节骨骼肌重塑，并以类似于运动的方式对骨骼肌产生模拟作用。它提供了基于现代生物技术和概念的金银花在改善肌肉健康方面的传统功能的科学解释。本研究为山楂在骨骼肌中作为运动模拟物的应用奠定了理论基础。Barbarum 提取物调节骨骼肌重塑，并以类似于运动的方式对骨骼肌产生模拟作用。它提供了基于现代生物技术和概念的金银花在改善肌肉健康方面的传统功能的科学解释。本研究为山楂在骨骼肌中作为运动模拟物的应用奠定了理论基础。Barbarum 提取物调节骨骼肌重塑，并以类似于运动的方式对骨骼肌产生模拟作用。它提供了基于现代生物技术和概念的金银花在改善肌肉健康方面的传统功能的科学解释。本研究为山楂在骨骼肌中作为运动模拟物的应用奠定了理论基础。