This study aimed to evaluate the influence of dietary supplementation with curcumin in a native (CUR) or solid nanoparticles (CURNPs) form as natural antioxidants on productive traits and some physiological functions of heat‐stressed growing rabbits. Total of 100 weaned APRI line rabbits (5 weeks old) was distributed according to body weight (BW) into five treatments (n = 20). Rabbits in the first treatment were fed a basal diet (BD, control), while those in treatments 2, 3, 4 and 5 were fed BD containing CUR (25 or 50 mg) and CURNPs (2.5 or 5 mg) per kg diet up to 13 week of age. The mean of air temperature and relative humidity during the growing period were 32.77°C and 43.23% respectively. Final BW, daily weight gain, feed conversion ratio and viability were positively affected by treatments compared with the control diet. Also, CUR and CURNPs treatments significantly increased total proteins, immunoglobulins, total antioxidants capacity, superoxide dismutase, glutathione peroxidase and glutathione in blood serum and hepatic tissues and significantly decreased serum total lipids, total cholesterol, triglycerides, low‐density lipoproteins, urea, aspartate transaminases and malondialdehyde (MDA) in hepatic tissues. Albumin and high‐density lipoproteins were significantly increased, while alanine transaminases and MDA were significantly decreased by both CURNPs levels. The CUR or CURNPs supplementation may enhance productive performance, lipid profile, liver function, immunity and antioxidant activity, with reducing liver lipid peroxidation of heat‐stressed growing rabbits. The best results were obtained by adding 2.5 mg CURNPs/kg diet under the experimental condition of this study.

中文翻译：

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姜黄素作为天然或纳米颗粒形式对热应激生长兔的生产效率、肝肾功能、抗氧化状态和免疫力的有益影响。

本研究旨在评估天然抗氧化剂（CUR）或固体纳米颗粒（CURNPs）形式的姜黄素作为天然抗氧化剂的膳食补充剂对热应激生长兔的生产性状和一些生理功能的影响。总共 100 只断奶 APRI 系兔（5 周龄）根据体重 (BW) 分为五个处理 ( n = 20）。第一次处理中的兔子喂食基础饲料（BD，对照），而处理 2、3、4 和 5 中的兔子喂食含有 CUR（25 或 50 毫克）和 CURNP（2.5 或 5 毫克）的 BD/kg 日粮到 13 周大。生长期平均气温和相对湿度分别为32.77℃和43.23%。与对照日粮相比，处理对最终体重、日增重、饲料转化率和生存力产生积极影响。此外，CUR 和 CURNPs 治疗显着增加血清和肝组织中的总蛋白、免疫球蛋白、总抗氧化能力、超氧化物歧化酶、谷胱甘肽过氧化物酶和谷胱甘肽，并显着降低血清总脂质、总胆固醇、甘油三酯、低密度脂蛋白、尿素、肝组织中的天冬氨酸转氨酶和丙二醛（MDA）。白蛋白和高密度脂蛋白显着增加，而丙氨酸转氨酶和 MDA 显着降低。补充 CUR 或 CURNPs 可以提高生产性能、脂质分布、肝功能、免疫和抗氧化活性，减少热应激生长兔的肝脏脂质过氧化。在本研究的实验条件下，通过添加 2.5 mg CURNPs/kg 饮食获得最佳结果。降低热应激生长兔肝脏脂质过氧化作用。在本研究的实验条件下，通过添加 2.5 mg CURNPs/kg 饮食获得最佳结果。降低热应激生长兔肝脏脂质过氧化。在本研究的实验条件下，通过添加 2.5 mg CURNPs/kg 饮食获得最佳结果。