Immunocyte single cell analysis of vaccine-induced narcolepsy.,European Journal of Immunology

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Immunocyte single cell analysis of vaccine-induced narcolepsy.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-07-15 , DOI: 10.1002/eji.202048633
Alexander Lind ₁ , Falastin Salami ₁ , Anne-Marie Landtblom ₂ , Lars Palm ₁ , Åke Lernmark ₁ , Jörgen Adolfsson ₃ , Helena Elding Larsson ₁

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Increased incidence of narcolepsy type 1 (NT1) was observed following Pandemrix®‐vaccination, initiated as a preventive measure against the 2009 Influenza pandemic. Here, single cell analysis was conducted to suggest a lower number of CD8⁺CD27⁺ T cells among these patients. These findings provide understanding into the autoimmune pathogenesis of NT1.

中文翻译：

疫苗诱发的发作性睡病的免疫细胞单细胞分析。

预防接种Pandemrix®疫苗后，观察到发作性睡病1型（NT1）的发病率增加，这是针对2009年流感大流行的预防措施。在这里，进行单细胞分析表明这些患者中CD8 ⁺ CD27 ⁺ T细胞的数量较少。这些发现提供了对NT1自身免疫发病机理的理解。

更新日期：2020-07-15

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