It is increasingly evident that the molecular and biological functions of long non‐coding RNAs (lncRNA) are vital for understanding the molecular biology and progression of cancer. The lncRNA‐HEIH, a newly identified lncRNA, has been demonstrated to be up‐regulated in hepatocellular cancer. However, little is known about its role in oesophageal squamous cell carcinoma (ESCC). In the present study, an obvious up‐regulation of lncRNA‐HEIH was observed in ESCC compared to the adjacent normal tissues. Meanwhile, patients with high expression of lncRNA‐HEIH have significantly poorer prognosis than those with low expression. We further found that lncRNA‐HEIH was associated with enhancer of zeste homolog 2 (EZH2) and that this association led to the repression of TP53. These findings indicate that lncRNA‐HEIH may serve as a prognostic marker and a potential therapeutic target for ESCC.

中文翻译：

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长链非编码 RNA HEIH 通过 zeste 同源物 2 增强子抑制食管鳞状细胞癌中 TP53 的表达。


越来越明显的是，长链非编码 RNA (lncRNA) 的分子和生物学功能对于理解癌症的分子生物学和进展至关重要。 lncRNA-HEIH是一种新发现的lncRNA，已被证明在肝细胞癌中表达上调。然而，人们对其在食管鳞状细胞癌（ESCC）中的作用知之甚少。在本研究中，与邻近正常组织相比，在 ESCC 中观察到 lncRNA-HEIH 明显上调。同时，lncRNA-HEIH高表达的患者预后明显差于低表达的患者。我们进一步发现 lncRNA-HEIH 与 zeste 同源物 2 (EZH2) 增强子相关，并且这种关联导致TP53的抑制。这些发现表明lncRNA-HEIH可能作为食管鳞癌的预后标志物和潜在的治疗靶点。