Functionalization of Graphene Oxide with Porphyrins: Synthetic Routes and Biological Applications.,ChemPlusChem

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Functionalization of Graphene Oxide with Porphyrins: Synthetic Routes and Biological Applications.
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-07-30 , DOI: 10.1002/cplu.202000455
Ana R Monteiro _{1,

2} , M Graça P M S Neves ₂ , Tito Trindade ₁

Affiliation

Among the available carbon nanomaterials, graphene oxide (GO) has been widely studied because of the possibility of anchoring different chemical species for a large number of applications, including those requiring water‐compatible systems. This Review summarizes the state‐of‐the‐art of synthetic routes used to functionalize GO, such as those involving multiple covalent and non‐covalent bonds to organic molecules, functionalization with nanoparticles and doping. As a recent development in this field, special focus is given to the formation of nanocomposites comprising GO and porphyrins, and their characterization through spectroscopic techniques (such as UV‐Vis, fluorescence, Raman spectroscopy), among others. The potential of such hybrid systems in targeted biological applications is also discussed, namely for cancer therapies relying on photodynamic and photothermal therapies and for the inhibition of telomerase enzyme. Lastly, some promising alternative materials to GO are presented to overcome current challenges of GO‐based research and to inspire future research directions in this field.

中文翻译：

氧化石墨烯与卟啉的功能化：合成途径和生物学应用。

在可用的碳纳米材料中，氧化石墨烯（GO）已被广泛研究，因为它有可能在许多应用中锚定不同的化学物种，包括那些需要与水相容的系统。这篇综述总结了用于GO功能化的最新合成路线，例如涉及与有机分子的多个共价和非共价键，纳米粒子功能化和掺杂的合成路线。作为该领域的最新进展，特别关注包括GO和卟啉的纳米复合材料的形成，以及它们通过光谱技术（例如UV-Vis，荧光，拉曼光谱）的表征。还讨论了这种混合系统在目标生物学应用中的潜力，即用于依赖光动力和光热疗法的癌症疗法以及抑制端粒酶的疗法。最后，提出了一些有希望的GO替代材料，以克服基于GO的研究的当前挑战，并激发该领域的未来研究方向。

更新日期：2020-08-26

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