While abnormal neurodevelopment contributes to schizophrenia (SCZ) risk, there is also evidence to support a role for immune dysfunction in SCZ. BCL11B , associated with SCZ in genome‐wide association study (GWAS), is a transcription factor that regulates the differentiation and development of cells in the central nervous and immune systems. Here, we use functional genomics data from studies of BCL11B to investigate the contribution of neuronal and immune processes to SCZ pathophysiology. We identified the gene targets of BCL11B in brain striatal cells (n = 223 genes), double negative 4 (DN4) developing T cells (n = 114 genes) and double positive (DP) developing T cells (n = 518 genes) using an integrated analysis of RNA‐seq and ChIP‐seq data. No gene‐set was enriched for genes containing common variants associated with SCZ but the DP gene‐set was enriched for genes containing missense de novo mutations (DNMs; p = .001) using data from 3,447 SCZ trios. Post hoc analysis revealed the enrichment to be stronger for DP genes negatively regulated by BCL11B. Biological processes enriched for genes negatively regulated by BCL11B in DP gene‐set included immune system development and cytokine signaling. These analyses, leveraging a GWAS‐identified SCZ risk gene and data on gene expression and transcription factor binding, indicate that DNMs in immune pathways contribute to SCZ risk.

中文翻译：

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在精神分裂症患者中发现的从头突变丰富了BCL11B在T细胞发育过程中调控的基因。

虽然异常的神经发育会导致精神分裂症（SCZ）风险，但也有证据支持SCZ中免疫功能障碍的作用。BCL11B与全基因组关联研究（GWAS）中的SCZ相关，是一种调节中枢神经和免疫系统中细胞分化和发育的转录因子。在这里，我们使用来自BCL11B研究的功能基因组学数据研究神经元和免疫过程对SCZ病理生理的贡献。我们使用B超识别了脑纹状体细胞（n = 223个基因），双阴性4（DN4）发育中的T细胞（n = 114个基因）和双阳性（DP）发育中的T细胞（n = 518个基因）中BCL11B的基因靶标。 RNA-seq和ChIP-seq数据的集成分析。对于含有与SCZ相关的常见变体的基因，没有丰富的基因集，但是对于含有错义从头突变（DNMs; p= .001），则使用3447 SCZ三重奏的数据。事后分析显示富集对BCL11B负调控的DP基因更强。DP基因组中BCL11B负调控基因丰富的生物过程包括免疫系统发育和细胞因子信号传导。这些分析利用GWAS鉴定的SCZ风险基因以及有关基因表达和转录因子结合的数据，表明免疫途径中的DNM有助于SCZ风险。