The use of in-silico finite element (FE) models has become more common in orthopedic applications and in the design of biomedical devices, since they can provide results comparable to in vitro experiments while maintaining lower cost.

The main downside of this kind of analysis is the high computing time, as it can reach hours or even days to complete; this limitation makes it then not suitable for time-sensitive applications, such as probabilistic analyses or helping clinicians in surgical pre-planning or intra-operative setting.

In-silico multibody (MB) simulations, on the other hand, are significantly faster than FE simulations (considering each component of the model as a rigid body); although deformability of each model component is a necessary feature in some applications (e.g. simulation of implant-bone micromotions), several outputs of interest in orthopedic applications, such as implant kinematics and contact forces, do not require a fully deformable model.

Therefore, this feasibility study aimed to develop a MB model of a human knee joint implanted with a Total Knee Arthroplasty; a 10 second flexion movement up to 105° was then simulated and the results compared with validated FE models results (under similar boundary conditions) from literature, to perform a preliminary validation in terms of kinematic and kinetic results between the two methods.

The agreement and relatively low computing time obtaining with this approach represent a promising starting point for subsequent studies and applications of such techniques in the clinical field.

在整形外科应用和生物医学设备的设计中，硅有限元 (FE) 模型的使用变得越来越普遍，因为它们可以提供与体外实验相当的结果，同时保持较低的成本。

这种分析的主要缺点是计算时间长，因为它可以达到数小时甚至数天才能完成；这种限制使其不适合时间敏感的应用，例如概率分析或帮助临床医生进行手术预先计划或术中设置。

另一方面，硅内多体 (MB) 模拟明显快于 FE 模拟（将模型的每个组件视为刚体）；尽管每个模型组件的可变形性在某些应用中是必要的特征（例如植入骨微运动的模拟），但在整形外科应用中感兴趣的几个输出，例如植入运动学和接触力，不需要完全可变形的模型。

因此，本可行性研究旨在开发植入全膝关节置换术的人体膝关节的 MB 模型；然后模拟长达 105° 的 10 秒屈曲运动，并将结果与​​文献中经过验证的有限元模型结果（在类似的边界条件下）进行比较，以对两种方法之间的运动学和动力学结果进行初步验证。

使用这种方法获得的一致性和相对较低的计算时间代表了此类技术在临床领域的后续研究和应用的有希望的起点。