Inter-individual differences in immune profiles of outbred rats screened for an emotional reactivity phenotype,Journal of Neuroimmunology

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Inter-individual differences in immune profiles of outbred rats screened for an emotional reactivity phenotype
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.jneuroim.2020.577349
Ceylan Isgor ₁ , Cigdem Aydin ₁ , Ozge Oztan ₁ , Stephania Libreros ₁ , Vijaya Iragavarapu-Charyulu ₁

Affiliation

Inter-individual differences in emotional reactivity predict susceptibility versus resilience to mood pathology. Using experimentally-naïve outbred rats that vary in locomotor reactivity to the mild stress of an inescapable novel environment [i.e., top and bottom 1/3rd of the population identified as high responders (HR) and low responders (LR) respectively], we determined baseline variations in immune functions. Innate and adaptive immune responses vary basally in LRHR rats, namely a shift towards TH1 in LRs and TH2 in HRs was observed. These inter-individual variations in immune profiles in LRHRs could have significant implications in mood alterations and immune reactivity to microbes and cancer.

中文翻译：

筛选情绪反应表型的远交大鼠免疫谱的个体差异

情绪反应的个体差异预测了对情绪病理的易感性与弹性。使用实验性幼稚的远交大鼠，这些大鼠对不可避免的新环境的轻度压力具有不同的运动反应性 [即，人口的顶部和底部 1/3 分别被确定为高反应者 (HR) 和低反应者 (LR)]，我们确定免疫功能的基线变化。LRHR 大鼠的先天性和适应性免疫反应基本不同，即观察到 LRs 中的 TH1 和 HRs 中的 TH2 的转变。LRHR 中免疫谱的这些个体间差异可能对情绪改变和对微生物和癌症的免疫反应具有重要意义。

更新日期：2020-10-01

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