Abstract A novel geminized amphiphilic polymer containing double cationic head groups and hydrophobic tails in each structural unit (denoted as PAGBn), has been prepared in our study. The self-assembly behavior on the solid/liquid interface was investigated by quartz crystal microbalance with dissipation (QCM-D), steady-state fluorescence, dynamic light scattering (DLS) and transmission electron microscope (TEM). A two-regime buildup can be observed, where the first regime is attributed to the rapid adsorption of polymers, while a rearrangements of pre-adsorbed molecules and their aggregation on the surface dominate the second regime, exhibiting a formation of aggregates in large sizes due to the effect of the charge density and hydrophobes on the self-assembly process. It exhibits a drastically enhanced killing efficiency of ∼99.9% against both of Staphylococcus aureus and Escherichia coli bacteria for PAGBn compared with other traditional single-chained polymers, through the reinforced synergistic effect of electrostatic and hydrophobic interactions, and the formation of large-sized polymer aggregates, encompassing and killing the bacteria more efficiency. Our findings reveal the antibacterial mechanism and the correlation between antibacterial activity and aggregates structure, providing a basis for the development of super-antibacterial materials in the infection resistant applications.

中文翻译：

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通过结构控制和自组装调节增强双生阳离子两亲聚合物的抗菌活性

摘要 在我们的研究中，我们制备了一种在每个结构单元中都含有双阳离子头基和疏水尾基的双亲双亲聚合物（表示为 PAGBn）。通过石英晶体微天平耗散（QCM-D）、稳态荧光、动态光散射（DLS）和透射电子显微镜（TEM）研究固/液界面上的自组装行为。可以观察到两个机制的积累，其中第一个机制归因于聚合物的快速吸附，而预吸附分子的重排及其在表面上的聚集支配了第二个机制，表现出大尺寸聚集体的形成电荷密度和疏水物对自组装过程的影响。它表现出显着提高的杀灭效率~99。与其他传统单链聚合物相比，PAGBn 对金黄色葡萄球菌和大肠杆菌的抑制率为 9%，通过静电和疏水相互作用的增强协同作用，形成大尺寸聚合物聚集体，更有效地包围和杀灭细菌. 我们的研究结果揭示了抗菌机制以及抗菌活性与聚集体结构之间的相关性，为在抗感染应用中开发超级抗菌材料提供了基础。包围和杀灭细菌的效率更高。我们的研究结果揭示了抗菌机制以及抗菌活性与聚集体结构之间的相关性，为在抗感染应用中开发超级抗菌材料提供了基础。包围和杀灭细菌的效率更高。我们的研究结果揭示了抗菌机制以及抗菌活性与聚集体结构之间的相关性，为在抗感染应用中开发超级抗菌材料提供了基础。