MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are both types of noncoding RNA. They have been demonstrated to be involved in the regulation of various human inflammatory diseases and can be used as biomarkers for disease diagnosis and prognosis, and even be developed into new drugs. Gout is an arthritic disease caused by the deposition of monosodium urate crystal (MSU) in the joints, which can lead to acute inflammation and damage adjacent tissue. Recent studies have shown that miRNAs and lncRNAs mediate the progress of gout. Based on the pathogenesis of gout, including hyperuricemia, MSU deposition, acute gouty arthritis and gouty bone erosion, this paper reviewed the role of miRNAs and lncRNAs in the processes and the possible therapeutic targets of miRNAs and lncRNAs in gout.

MicroRNA（miRNA）和长非编码RNA（lncRNA）都是非编码RNA的类型。它们已被证明参与多种人类炎症性疾病的调控，并可用作疾病诊断和预后的生物标志物，甚至被开发为新药。痛风是一种关节炎病，是由尿酸单钠晶体（MSU）在关节中沉积引起的，这可能导致急性炎症并损害邻近组织。最近的研究表明，miRNA和lncRNA介导痛风的进展。基于痛风的发病机理，包括高尿酸血症，MSU沉积，急性痛风性关节炎和痛风性骨侵蚀，本文综述了miRNA和lncRNA在痛风过程中的作用以及miRNA和lncRNA的治疗靶点。