The effect of CYP3A4 genetic variants on the susceptibility to chronic obstructive pulmonary disease in the Hainan Han population.,Genomics

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The effect of CYP3A4 genetic variants on the susceptibility to chronic obstructive pulmonary disease in the Hainan Han population.
Genomics ( IF 3.4 ) Pub Date : 2020-07-30 , DOI: 10.1016/j.ygeno.2020.07.043
Huifang Shi ₁ , Jianguang Xu ₁ , Qiong Feng ₂ , Juan Sun ₃ , Yixiu Yang ₃ , Jie Zhao ₂ , Xiaoli Zhou ₃ , Huan Niu ₃ , Ping He ₃ , Jianfang Liu ₂ , Quanni Li ₃ , Yipeng Ding ₃

Affiliation

Purpose

Genetic polymorphisms act a crucial role in chronic obstructive pulmonary disease (COPD) progression. This study aimed to investigate the correlation between CYP3A4 variants and COPD risk.

Methods

We carried out a case-control study of 821 individuals (313 patients and 508 healthy subjects) to identify the correlation of CYP3A4 SNPs with COPD risk in the Hainan Han population. The association was evaluated by Odds ratios (OR) and 95% confidence intervals (CI).

Results

Our study showed that rs4646437 polymorphism was related to a significantly increased susceptibility to COPD (OR 1.45, 95% CI = 1.10–1.90, p = 0.008). Stratified analyses indicated that rs4646437 polymorphism was significantly related to an increased risk of COPD in males (OR 1.95, 95% CI = 1.19–3.20, p = 0.008). However, rs4646440 played a protective role in females (OR 0.54, 95% CI = 0.31–0.93, p = 0.024). Rs4646437 was found to significantly improve the risk of COPD in smokers (OR 1.67, 95% CI = 1.12–2.48, p = 0.011). While rs4646440 had a significantly lower susceptibility to COPD in non-smokers (OR 0.64, 95% CI = 0.45–0.90, p = 0.010). Haplotype analysis revealed that A_rs4646440T_rs35564277 haplotype of CYP3A4 was found to increase the risk of COPD in non-smokers (OR 1.71, 95% CI = 1.04–2.82, p = 0.034).

Conclusion

Our result gives a new understanding of the association between CYP3A4 gene and COPD in the Hainan Han population.

中文翻译：

CYP3A4基因变异对海南汉族慢性阻塞性肺疾病易感性的影响.

目的

遗传多态性在慢性阻塞性肺疾病 (COPD) 进展中起着至关重要的作用。本研究旨在调查CYP3A4变异与 COPD 风险之间的相关性。

方法

我们对 821 名个体（313 名患者和 508 名健康受试者）进行了病例对照研究，以确定海南汉族人群中CYP3A4 SNP 与 COPD 风险的相关性。相关性通过优势比 (OR) 和 95% 置信区间 (CI) 进行评估。

结果

我们的研究表明，rs4646437 多态性与 COPD 易感性显着增加有关（OR 1.45，95% CI = 1.10–1.90，p = 0.008）。分层分析表明，rs4646437 多态性与男性 COPD 风险增加显着相关（OR 1.95，95% CI = 1.19–3.20，p = 0.008）。然而，rs4646440 在女性中发挥了保护作用（OR 0.54，95% CI = 0.31–0.93，p = 0.024）。发现 Rs4646437 可显着改善吸烟者患 COPD 的风险（OR 1.67，95% CI = 1.12–2.48，p = 0.011）。而 rs4646440 在非吸烟者中对 COPD 的易感性显着降低（OR 0.64，95% CI = 0.45–0.90，p = 0.010）。单倍型分析显示 A _rs4646440发现CYP3A4 的T _rs35564277单倍型会增加非吸烟者患 COPD 的风险（OR 1.71，95% CI = 1.04–2.82，p = 0.034）。