C-Type Lectin Receptors (CTLR) are involved in the activation of innate and adaptative immune responses. Among these receptors, the Dendritic Cell-Specific ICAM-3-Grabbing nonintegrin (DC-SIGN/CD209) has become a hot topic due to its ability to bind and facilitate the infections processes of several pathogens. Although well characterized in mammals, little documentation exists about the receptor in salmonid fishes. Here, we report the sequence and expression analysis of eight DC-SIGN-like genes in Salmo salar. Each receptor displays structural similarities to DC-SIGN molecules described in mammals, including internalization motifs, a neck region with heptad repeats, and a Ca⁺²-dependent carbohydrate recognition domain. The receptors are expressed in multiple tissues of fish, and fish cell lines, with differential expression upon infection with viral and bacterial pathogens. The identification of DC-SIGN-like receptors in Salmo salar provides new information regarding the structure of the immune system of salmon, potential markers for cell subsets, as well as insights into DC-SIGN conservation across species.

C 型凝集素受体 (CTLR) 参与先天性和适应性免疫反应的激活。在这些受体中，树突状细胞特异性 ICAM-3-抓取非整联蛋白 (DC-SIGN/CD209) 因其结合和促进多种病原体感染过程的能力而成为热门话题。尽管在哺乳动物中得到了很好的表征，但关于鲑鱼中受体的文献很少。在这里，我们报告了鲑鱼中八个 DC-SIGN 样基因的序列和表达分析。每个受体都显示出与哺乳动物中描述的 DC-SIGN 分子的结构相似性，包括内化基序、带有七肽重复序列的颈部区域和 Ca ⁺²依赖的碳水化合物识别域。受体在鱼的多种组织和鱼细胞系中表达，在感染病毒和细菌病原体时有差异表达。鉴定DC-SIGN样受体在大西洋鲑提供了有关的鲑鱼，潜在的标志物细胞亚群的免疫系统的结构的新信息，以及见解跨物种DC-SIGN的保护。