Phosphofructokinase-M (PFKM) is a key enzyme in glycolysis. The expression and activity of PFKM is closely related to the occurrence and development of malignant tumors, but its role in the regulation of renal cell carcinoma (RCC) is still unknown. We found that the expression of PFKM was lower in RCC tumor tissue than in adjacent normal tissues, and that low expression of PFKM was related to the poor overall survival of RCC patients. In addition, our results showed that FOXO3 mediated PFKM inhibited the growth, migration and invasion of RCC cells, suggesting that PFKM is a protective factor for RCC.

中文翻译：

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磷酸果糖激酶-M 通过调节肾细胞癌细胞中的 FOXO3 通路来抑制细胞生长。

磷酸果糖激酶-M (PFKM) 是糖酵解中的关键酶。 PFKM的表达和活性与恶性肿瘤的发生、发展密切相关，但其在肾细胞癌（RCC）中的调控作用尚不清楚。我们发现PFKM在RCC肿瘤组织中的表达量低于癌旁正常组织，且PFKM的低表达量与RCC患者总生存期较差有关。此外，我们的结果表明FOXO3介导的PFKM抑制RCC细胞的生长、迁移和侵袭，表明PFKM是RCC的保护因子。