An “off-on” electrochemiluminescence aptasensor for microcystin-LR assay based on the resonance energy transfer from PTCA/NH2-MIL-125(Ti) to gold nanoparticles,Microchimica Acta

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An “off-on” electrochemiluminescence aptasensor for microcystin-LR assay based on the resonance energy transfer from PTCA/NH2-MIL-125(Ti) to gold nanoparticles
Microchimica Acta ( IF 5.3 ) Pub Date : 2020-07-30 , DOI: 10.1007/s00604-020-04453-x
Jingxian Li ₁ , Ding Jiang _{1,

2} , Xueling Shan _{1,

2} , Wenchang Wang _{1,

2} , Zhidong Chen _{1,

2}

Affiliation

A novel “off-on” electrochemiluminescence (ECL) aptasensor based on ECL resonance energy transfer (RET) system from 3,4,9,10-perylenetetracar-boxylic acid/the metal-organic frameworks NH2-MIL-125(Ti) (PTCA/NH2-MIL-125) to Au nanoparticles (Au NPs) was put forward for microcystin-LR (MC-LR) assay. The electrochemiluminescence (ECL) emission spectra of PTCA/NH2-MIL-125 show excellent spectral overlap with the UV-vis absorption spectrum of Au NPs. A linear response ranging from 10 fM (9.95 × 10−6 μg L−1) to 0.1 μM (99.5 μg L−1) was obtained, and the detection limit was 3.6 fM (3.58 × 10−6 μg L−1) under optimal conditions at a potential of − 1.6 V (S/N = 3). Besides, the prepared ECL-RET MC-LR aptasensor exhibited good selectivity and stability. Graphical abstract Graphical abstract

中文翻译：

基于从 PTCA/NH2-MIL-125(Ti) 到金纳米粒子的共振能量转移，用于微囊藻毒素-LR 测定的“关断”电化学发光适体传感器

基于ECL共振能量转移（RET）系统的新型“关断”电化学发光（ECL）适体传感器来自3,4,9,10-苝四羧酸/金属有机骨架NH2-MIL-125（Ti）（ PTCA/NH2-MIL-125) 到 Au 纳米粒子 (Au NPs) 被提出用于微囊藻毒素-LR (MC-LR) 测定。PTCA/NH2-MIL-125 的电化学发光 (ECL) 发射光谱与 Au NPs 的 UV-vis 吸收光谱显示出极好的光谱重叠。线性响应范围为 10 fM (9.95 × 10−6 μg L−1) 到 0.1 μM (99.5 μg L−1)，检测限为 3.6 fM (3.58 × 10−6 μg L−1)。电位为 − 1.6 V (S/N = 3) 时的最佳条件。此外，制备的ECL-RET MC-LR适体传感器表现出良好的选择性和稳定性。图形摘要图形摘要

更新日期：2020-07-30

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