The SARS-CoV-2 virus pandemic has provoked drastic countermeasures including shutdowns of public services. We wanted to describe the effects of a 6 week shutdown of a large German botulinum toxin (BT) outpatient clinics on patients and their well-being. 45 patients (age 61.9 ± 9.8 years, 29 females, 16 males) receiving BT therapy (319.3 ± 201.9MU-equivalent, treatment duration 8.3 ± 5.5 years) were surveyed with a standardised questionnaire. The shutdown delayed BT therapy by 6.6 ± 2.3 weeks. 93% of the patients noticed increased muscle cramps and 82% increased pain reducing their quality of life by 40.2 ± 19.5%. For 23 patients with cervical dystonia this reduction was 41.1 ± 18.3%, for 3 patients with blepharospasm 33.3 ± 15.3%, for 9 patients with spasticity 37.8 ± 15.6%, for 4 patients with pain conditions 37.4 ± 35.7% and for 3 patients with hemifacial spasm 27.5 ± 17.1%. After the shutdown 66% of patients perceived BT therapy as more important than before, 32% perceived it as unchanged. For all patients long-term availability of BT therapy was very important or important. 98% of the patients perceived the shutdown as inadequate and felt their patient rights not respected. The shutdown confirmed the considerable burden of disease caused by dystonia, spasticity, hemifacial spasm and various pain conditions and the importance of BT therapy to treat them. Any shutdown severely affects these patients and needs to be avoided.

SARS-CoV-2病毒大流行引发了严厉的对策，包括关闭公共服务。我们想描述一家大型德国肉毒杆菌毒素（BT）门诊诊所停诊6周对患者及其健康的影响。用标准问卷调查了45例接受BT治疗（等效于319.3±201.9MU，治疗时间8.3±5.5年）的患者（年龄61.9±9.8岁，女性29例，男性16例）。停药使BT治疗延迟了6.6±2.3周。93％的患者注意到肌肉痉挛增加，而82％的疼痛增加，生活质量降低了40.2±19.5％。对于23例患有颈肌张力障碍的患者，减少率为41.1±18.3％，对于3例睑裂痉挛患者为33.3±15.3％，对于9例痉挛患者为37.8±15.6％，对于4例疼痛情况为37.4±35。7％，3例面肌痉挛患者为27.5±17.1％。停药后，有66％的患者认为BT治疗比以前更重要，有32％的患者认为治疗没有改变。对于所有患者，BT治疗的长期可用性非常重要或重要。98％的患者认为停药不足，并认为患者的权利得不到尊重。停药证实了由肌张力障碍，痉挛，面肌痉挛和各种疼痛状况引起的巨大疾病负担，以及BT治疗这些疾病的重要性。任何停机都会严重影响这些患者，需要避免。98％的患者认为停药不足，并认为患者的权利得不到尊重。停药证实了由肌张力障碍，痉挛，面肌痉挛和各种疼痛状况引起的巨大疾病负担，以及BT治疗这些疾病的重要性。任何停机都会严重影响这些患者，需要避免。98％的患者认为停药不足，并认为患者的权利得不到尊重。停药证实了由肌张力障碍，痉挛，面肌痉挛和各种疼痛状况引起的巨大疾病负担，以及BT治疗这些疾病的重要性。任何停机都会严重影响这些患者，需要避免。