Unusual absence of FRET in triazole bridged coumarin-hydroxyquinoline, an active sensor for Hg2+ detection.,Photochemical & Photobiological Sciences

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Unusual absence of FRET in triazole bridged coumarin-hydroxyquinoline, an active sensor for Hg2+ detection.
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2020-07-29 , DOI: 10.1039/d0pp00140f
Surajit Mondal ₁ , Niladri Patra ₁ , Hari Pada Nayek ₁ , Sumit K Hira ₂ , Soumit Chatterjee ₁ , Swapan Dey ₁

Affiliation

A triazole-bridged coumarin conjugated quinoline sensor has been ‘click’-synthesized by Cu(I) catalyzed Huisgen cycloaddition, and it exhibited high selectivity for toxic Hg²⁺. Surprisingly, no evidence of energy transfer from the quinoline moiety to coumarin has been found, substantiated by time-resolved fluorescence study. The possible binding mode of this sensor to Hg²⁺ has been established via NMR study, steady-state and time-resolved fluorescence spectroscopy, which is further supported by TDDFT calculations. The sensor has been found to be cell membrane permeable and non-toxic, and hence is suitable for intracellular Hg²⁺ detection.

中文翻译：

三唑桥联的香豆素-羟基喹啉（一种检测Hg2 +的活性传感器）中不常见FRET。

三唑桥联的香豆素共轭喹啉传感器已被Cu（I）催化的惠斯根环加成反应“点击”合成，并且对毒性Hg ²⁺具有很高的选择性。出乎意料的是，没有发现能量从喹啉部分转移到香豆素的证据，通过时间分辨荧光研究证实了这一点。该传感器与Hg ²⁺的可能结合模式已经通过NMR研究，稳态和时间分辨荧光光谱法确定，TDDFT计算进一步支持了该传感器。已发现该传感器可透过细胞膜且无毒，因此适用于细胞内Hg ²⁺检测。

更新日期：2020-09-16

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